国际眼科纵览 ›› 2014, Vol. 38 ›› Issue (1): 31-36.doi: 10 3706/ cma. j. issn.16735803 2014 01 008

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正常眼压性青光眼发病机制研究进展

雷登凤  樊宁  何湘珍  刘旭阳   

  1. 421001湖南衡阳,南华大学附属第二医院眼科(雷登凤、何湘珍);518040 暨南大学附属深圳市眼科医院(樊宁、刘旭阳)
  • 收稿日期:2013-09-20 出版日期:2014-02-22 发布日期:2014-02-27
  • 通讯作者: 刘旭阳,Email: xliu1213@126.com E-mail:xliu1213@126.com

Advances in pathogenesis of normal tension glaucoma

LEI Dengfeng1, FAN Ning2, HE Xiangzhen1, LIU Xuyang2   

  1. 1  Department of Ophthamology, the Second Affiliated Hospital, University of South China, Hengyang 421001, China; 2 Shenzhen Eye Hospital, Jinan University, Shenzhen 518040, China
  • Received:2013-09-20 Online:2014-02-22 Published:2014-02-27
  • Contact: LIU Xuyang, Email: xliu1213@126.com E-mail:xliu1213@126.com

摘要: 正常眼压性青光眼在临床上被认为是眼底和视野出现特征性青光眼损害,而眼压始终正常的一种状态。正常眼压性青光眼在分类上被认为是原发性开角型青光眼的一个亚型,迄今有关其视神经损伤机制的研究主要集中在机械压力因素、血管及血流动力学因素、免疫调节因素及遗传因素等方面。

Abstract: Normal tension glaucoma (NTG)  is defined as the clinical situation with the characteristic glaucomtous damages in optic nerve and visual field with the persistent normal intarocular pressure. NTG is a special form of primary openangle glaucoma, but yet the mechanisms underlying the optic neuropathy remain unknown. The purpose of this review is to discuss the recent progress in the mechanisms of NTG, which includes mechanical stress, hemodynamic factors, immunomodulatory, and an improved knowledge of genetics.