国际眼科纵览 ›› 2015, Vol. 39 ›› Issue (1): 21-25.doi: 103706/ cma.j.issn.1673\|5803201501004

• 综述 • 上一篇    下一篇

儿童非感染性葡萄膜炎的药物治疗

 王敏  张美芬   

  1.  100005 中国医学科学院 北京协和医学院 北京协和医院眼科
  • 收稿日期:2014-12-03 出版日期:2015-02-22 发布日期:2015-03-03
  • 通讯作者: 张美芬,Email:meifen_zhang@hotmail.com E-mail:meifen_zhang@hotmail.com

Medication treatment of  pediatric noninfectious uveitis

WANG Min,ZHANG Mei-fen   

  1. Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China
  • Received:2014-12-03 Online:2015-02-22 Published:2015-03-03
  • Contact: ZHANG Mei-fen, Email: meifen_zhang@hotmail.com E-mail:meifen_zhang@hotmail.com

摘要: 儿童葡萄膜炎占所有葡萄膜炎的5%~10%,多数起病隐匿、病程迁延,常合并多种眼部并发症。儿童葡萄膜炎多为非感染性,其中绝大多数为特发性,最常见的全身病因为幼年特发性关节炎。儿童葡萄膜炎治疗棘手,常用药物为糖皮质激素、抗代谢药、T细胞抑制剂。近年来生物制剂的使用为儿童非感染性葡萄膜炎的治疗提供了新方法。玻璃体腔植入糖皮质激素缓释装置可长时间控制眼内炎症,但在儿童中使用的安全性及有效性仍待进一步研究。

Abstract: Pediatric uveitis is accounting for  5%~10% of all the uveitis. Most individuals have an insidious onset and persistent duration, ocular complications are common. Most pediatric uveitis are noninfectious and idiopathic, the most common etiologic diagnosis is juvenile idiopathic arthritis. Treatment of pediatric uveitis is tough, the mainstays of therapy include corticosteroids, antimetabolites, and T\|cell inhibitors. In the last decade, biologic agents provide us new methods for treating pediatric uveitis. Intravitreal corticosteroid delivery devices have enhanced our ability to provide longer\|lasting local disease control, but there are very limited data showing the efficacy and safety in children.