Abstract: Heparanase (HPSE) in the endo-D-heparanase; retinal neovascularization;  cancer; coagulation; eye
glucuronidase is the only mammalian heparin sulfate (HS)degrading enzymes, which cleaves heparan sulfate (HS) that links to heparin sulfate proteoglycans. HPSE is a single copy gene, which can promotes tumor invasion and metastasis,  angiogenesis, maintaining lens membrane structure, coagulation function,embryonic tissue development and other aspects of participation.Reports about the relationship between HPSE and ophthalmology diseases is less. The present studies found that HPSE was associated with the corneal inflammation and neovascularization,lens diseases, physiological structure and neovascularization of retina, proliferation and migration of retinal pigmeng epithelium cells.