Abstract: In high myopia, changes in anterior and posterior segment biometric parameters associated with axial elongation are strongly associated with the axial length itself. Evidence indicates that structural parameters such as corneal, scleral, choroidal, and retinal nerve fiber layer thickness are negatively correlated with axial length, while morphological and biomechanical parameters including anterior chamber depth, corneal deformation amplitude, and peripapillary atrophy area show positive correlations. Multimodal imaging reveals that these parameters are interconnected through a biomechanical and metabolic regulatory network, and their cascade abnormalities constitute a key mechanism underlying fundus pathology in high myopia. Future studies should integrate longitudinal cohorts and artificial intelligence modeling to elucidate the dynamics of this network and advance precise strategies for myopia control.

Key words: High myopia, Biological parameters, Correlation analysis, Myopia prevention and control