Abstract: Heat shock protein 47 (HSP47) is a collagen-specific molecular chaperone that mainly regulates collagen maturation. High expression of HSP47 can lead to excessive collagen deposition and is involved in the pathogenesis of multisystem diseases such as tissue fibrosis and tumor metastasis. Ocular tissues are rich in collagen, and changes in the expression of HSP47 may be closely associated with the onset and progression of ocular diseases. This article will summarize the roles and potential mechanisms of HSP47 in postoperative scarring after glaucoma filtration surgery, corneal diseases, vitreoretinal disorders, thyroid-associated ophthalmopathy, chronic graft-versus-host disease, posterior capsule opacification, and high myopia. Furthermore, it will discuss the development and clinical application of HSP47-targeted therapies, aiming to provide a theoretical basis for the precise prevention and treatment of ocular diseases

Key words: Heat shock protein 47, Fibrosis, Collagen, Ocular diseases