Abstract: Blepharokeratoconjunctivitis (BKC) refers to a group of chronic ocular surface diseases, which often involves the conjunctiva and cornea, and causes severe vision impairment. It’s easy to be misdiagnosed and missed diagnosed, because its onset is insidious and its clinical manifestations and signs are easily confused with other corneal and conjunctival diseases. It can cause amblyopia or severe visual impairment, especially for pediatric population. The treatment of BKC needs to control the inflammation of the eyelid margin first, with local treatment as the mainstay. Patients with severe disease, oral drug can be added. Non-steroidal anti-inflammatory drugs, glucocorticoids, immunosuppressants, can be added for corneal and conjunctival inflammation. Mild BKC should be treated with low\|concentration glucocorticoids or non-steroidal anti-inflammatory drugs. Moderate-to-severe BKC should be treated with high-concentration glucocorticoids or low-concentration glucocorticoids combined with immunosuppressive agents. Those with corneal ulcers need to use antibacterial eye ointments. Severe cases may require surgery.

Key words: blepharitis, keratoconjunctivitis, treatment