Abstract: The deformation of lamina cribrosa and the decrease of blood flow have been regarded as the first factors of optic nerve axon damage in glaucoma. Pathological intraocular pressure increase has been proved to be closely related to the occurrence and development of glaucoma. With the continuous improvement of OCT technology, the study of the pathogenesis of glaucoma by measuring the changes of lamina cribrosa and peripheral parameters with intraocular pressure has also been widely concerned around the world. A large number of studies have shown that the lamina cribrosa depth (LCD), the prelaminar tissue thickness (PTT), the lamina cribrosa curvature index (LCCI) and the optic nerve head vascular density are all correlated with intraocular pressure by OCT and OCT technology. Higher intraocular pressure can affect the progress of glaucoma through its dual effects on lamina cribrosa structure and blood flow. However, the role of intraocular pressure is not the only factor affecting the lamina cribrosa. (Int Rev Ophthalmol, 2021, 45: 145-151)

Key words: glaucoma, lamina cribrosa, intraocular pressure, optical coherence tomography, optical coherence tomography angiography