Abstract: The pathogenesis of myopia is that abnormal visual stimulation effect on retinal and cause the change of retinal signal factors, which is then transmitted to the sclera through the retinal pigment epithelium-choroid pathway, induces extracellular matrix (ECM) reconstruction and the sclera remodeling. Form-deprivation-myopia (FDM) is one of the commonly used models in guinea pigs to study myopia. The study on FDM induction in guinea pigs mainly focused on the intervention with different drugs such as nitric oxide synthase, melatonin, M receptor blockers, dopamines, intraocular pressure lowering drugs, peroxisome proliferator activated receptor α (PPAR α) agonists and antagonists, hypoxia inducible factor, which causes the changes of dopamine, matrix metalloproteinase-2 (MMP-2), tissue inhibitor matrix metalloproteinase-2 (TIMP-2), transforming growth factor-β (TGF-β) , α-smooth muscle actin (α-SMA) and type I collagen, thus affecting the process of FDM. (Int Rev Ophthalmol, 2021, 45: 256-262)

Key words: guinea pig, form-deprived myopia, retina, sclera