The role of retinal microglia in blinding eye diseases

doi:10.3760/cma.j.issn.1673-5803.2023.06.004

International Review of Ophthalmology ›› 2023, Vol. 47 ›› Issue (6): 498-503.doi: 10.3760/cma.j.issn.1673-5803.2023.06.004

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The role of retinal microglia in blinding eye diseases

Li Wanqian ¹, Hou Shengping²#br#

¹ Department of Ophthalmology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing 400016, China; ²Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing 100730, China

Received:2023-11-29 Online:2023-12-22 Published:2023-12-22
Contact: Hou Shengping, Email: sphou828@163.com
Supported by:
National Natural Science Foundation of China (82070951, 82271078)

Abstract

Abstract: Microglia are retinal resident immune cells, which are particularly critical for maintaining the dynamic balance of the retinal microenvironment. Microglia have diverse functions, strong plasticity, and activated microglia can play a dual role in protecting tissue and exacerbating damage in response to external stimuli. There is growing evidence that retinal microglia are involved in the development of a variety of blinding eye diseases, such as uveitis, age-related macular degeneration (AMD) and diabetic retinopathy (DR). (Int Rev Ophthalmol, 2023, 47: 498-503)

Key words: retina, microglia, immunity

Li Wanqian, Hou Shengping. The role of retinal microglia in blinding eye diseases [J]. International Review of Ophthalmology, 2023, 47(6): 498-503.

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The role of retinal microglia in blinding eye diseases

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