Abstract: Coats disease is characterized by retinal telangiectasia. Fundus fluorescein angiography (FFA) is the authentic standard for the diagnosis of retinal vasodilation and leakage in Coats disease. In addition, fundus photography and ocular B-ultrasound are also widely used in the diagnosis and evaluation of Coats disease. While considering the lack of specificity in the examination results, their assistance in the diagnosis and follow-up of Coats disease are limited. Optical coherence tomography (OCT) could display the structural changes of each layer of the retina and clarify the pathological tissues, providing plenty of information for the clinical diagnosis of Coats disease. Optical coherence tomography angiography (OCTA) and ultra-widefield fluorescein angiography (UWFA) could accurately evaluate the pathological condition of Coats disease. At the same time, ultra-widefield fundus photograph (UWF) and colored photography have supplemented more information with traditional fundus photography techniques. Therefore, the combination of UWF and UWFA with OCT and OCTA can provide more comprehensive information for the diagnosis of Coats disease, and provide a more comprehensive means of follow-up, evaluation and further understanding of the pathogenesis for the Coats disease. (Int Rev Ophthalmol, 2023, 47: 156-162)

Key words: fundus multimodal imaging, Coats disease, optical coherence tomography