International Review of Ophthalmology ›› 2023, Vol. 47 ›› Issue (6): 498-503.doi: 10.3760/cma.j.issn.1673-5803.2023.06.004

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The role of retinal microglia in blinding eye diseases 

Li Wanqian 1, Hou Shengping2#br#   

  1. 1 Department of Ophthalmology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing 400016, China; 2 Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing 100730, China
  • Received:2023-11-29 Online:2023-12-22 Published:2023-12-22
  • Contact: Hou Shengping, Email: sphou828@163.com
  • Supported by:
    National Natural Science Foundation of China (82070951,  82271078)

Abstract: Microglia are retinal resident immune cells, which are particularly critical for maintaining the dynamic balance of the retinal microenvironment. Microglia have diverse functions, strong plasticity, and activated microglia can play a dual role in protecting tissue and exacerbating damage in response to external stimuli. There is growing evidence that retinal microglia are involved in the development of a variety of blinding eye diseases, such as uveitis, age-related macular degeneration (AMD) and diabetic retinopathy (DR).  (Int Rev Ophthalmol, 2023, 47:  498-503)

Key words: retina, microglia, immunity