International Review of Ophthalmology ›› 2014, Vol. 38 ›› Issue (3): 156-159.doi: 10.3760/ cma. j. issn.1673-5803.2014.03.003

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Lyonization and eye diseases

 ZHAO  Ying-Xi, CHEN  Xiang-Wu   

  1. Department of Ophthalmology, Yiwu Hospital, Zhejiang University, Yiwu Zhejiang 322000, China
  • Received:2013-12-11 Online:2014-06-22 Published:2014-06-23
  • Contact: CHEN Xiang-wu, Email：chenxiangwu1797@gmail.com

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Abstract: Lyonization, also known as X chromosome inactivation, is a process that one of the two X chromosomes is inactivated in every somatic diploid cell during embryonic development in female mammals. Lyonization is involved in several X\|linked ocular diseases, such as choroideremia, X\|linked retinitis pigmentosa, and X\|linked ocular albinism. Insights of Lyonization may help in diagnosis and cure of ocular X\|linked recessive genetic diseases. (Int Rev Ophthalmol, 2014, 38: 156-159)