眼科

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20G玻璃体切除术对高血压病患者泪膜稳定性的影响

房修岭  姜虎林  张辽   

  1. 252000 山东省聊城市光明眼科医院
  • 收稿日期:2015-06-15 出版日期:2015-09-25 发布日期:2015-10-10
  • 通讯作者: 房修岭,Email:lanwoniu1985@126.com

Stability change of tear film after 20-gauge vitrectomy in patients with systemic hypertension

FANG Xiu-ling, JIANG Hu-lin, ZHANG Liao   

  1. Liaocheng Guangming Eye Hospital, Liaocheng Shandong  252000, China
  • Received:2015-06-15 Online:2015-09-25 Published:2015-10-10
  • Contact: FANG Xiu-ling, Email: lanwoniu1985@126.com

摘要:

目的 观察20G玻璃体切除术对高血压病患者泪膜稳定性的影响。设计 前瞻性比较性病例系列。研究对象 2013年7月至2014年2月在聊城市光明眼科医院行20G玻璃体切除术患者103例(103眼),其中伴高血压病者53例53眼(A组),无高血压病者50例50眼(B组)。均以对侧非手术眼作为对照。方法 于术前1天,术后1、3、7天,1及3个月进行泪膜稳定性检测。主要指标 基础泪液分泌试验(SIT)、泪膜破裂时间(BUT) 、角膜荧光素染色(CFS)评分、干眼不适症状(DES)评分。结果 与对照眼相比,A组患者术后1天、3天、7天术眼的DES评分高(Z=3.852、2.541、2.018,P=0.000、0.013、0.034)、BUT值短(t=4.073、4.521、3.545,P=0.000、0.000、0.008)、CFS评分高(Z=5.253、4.362、5.248,P均=0.000)、SIT值多(t=4.621、4.272、4.358,P均=0.000)。与对照眼相比,B组患者术后1天、3天、7天术眼的DES评分高(Z=4.324、3.263、2.432,P=0.000、0.002、0.018)、BUT值短(t=3.953、4.257、3.423,P=0.000、0.000、0.009)、CFS评分高(Z=5.221、4.305、5.253,P均=0.000)、SIT值多(t=4.257、4.238、4.137,P均=0.000)。与B 组手术眼相比,A组术后1天、3天DES评分高(Z=3.726、2.357,P=0.000、0.018),术后1天、7天、1个月BUT值短(t=2.224、2.157、2.010,P=0.028、0.032、0.046),术后1天、3天、1个月CFS评分高(Z=3.589、3.317、2.794,P=0.000、0.008、0.029),术后3天、7天SIT值多(t=4.724、3.486,P均=0.000)。结论 20G玻璃体切除手术后早期,高血压病患者较非高血压病患者泪膜稳定性及泪液分泌量一过性下降,晚期可逐渐好转,恢复至正常。对高血压病患者术后早期应重视促进眼表恢复。(眼科,2015, 24: 336-340)

关键词: 玻璃体切除术, 高血压病, 泪膜稳定性

Abstract:

 Objective To observe the changes in the stability of tear film after 20-gauge vitrectomy in patients with hypertension. Design Prospective comparative case series. Participants 103 cases (103 eyes) underwent 20-gauge vitrectomy were enrolled. 103 patients (103 eyes) were divided into 2 groups: 53 patients with hypertension (group A) and 50 eyes without system hypertension (group B). The contralateral eyes were regarded as their respective control group. Method The stability of tear film and associated symptoms of all cases on 1 day before surgery and 1day, 3days, 7days, 1month, and 3 months after surgery were tested and recorded. The changes between two groups and the changes within each group at different time were compared and analyzed. Main Outcome Measures Schirmer I test (SIT), break-up time (BUT), corneal fluorescein staining (CFS) scores and dry eyes symptom (DES) scores. Results Compared to non-surgical controlled eyes of group A, CFS score (Z=5.253, 4.362, 5.248; all P=0.000), DES score (Z=3.852, 2.541, 2.018; P=0.000, 0.013, 0.034), and BUT value (t=4.073, 4.521, 3.545; P=0.000, 0.000, 0.008) of surgical eyes was higher, and SIT length (t=4.621, 4.272, 4.358; all P=0.000) was shorter at the 1st, 3rd, and 7th day after vitrectomy. Compared to non-surgical controlled eyes of group B, CFS score (Z=5.221, 4.305, 5.253; all P=0.000), DES score (Z=4.324, 3.263, 2.432; P=0.000, 0.002, 0.018), and BUT value (t=3.953, 4.257, 3.423; P=0.000, 0.000, 0.009) of surgical eyes was higher, and SIT length (t=4.257, 4.238, 4.137; all P=0.000) was shorter at the 1st, 3rd, and 7th day after vitrectomy. The DES score of Group A was higher than that of Group B at the 1st, and 3rd day after vitrectomy (Z=3.726, 2.357; P=0.000, 0.018) and the CFS score of Group A was higher than that of Group B at the 1st, 3rd day, and 1 month after vitrectomy (Z=3.589, 3.317, 2.794; P=0.000, 0.008, 0.029). The BUT value of Group A was lower than that of Group B at the 1st, 7th day, and 1 month after vitrectomy (t=2.224, 2.157, 2.010; P=0.028, 0.032, 0.046) and the SIT length of Group A was longer than that of Group B at the 3rd, and 7th day after vitrectomy (t=4.724, 3.486; all P=0.000). Conclusion In the early period of post 20-gauge vitrectomy, the stability of tear film and the amount of tear secretion in patients with systemic hypertension is poorer than without hypertension patients. This situation will improve and recover to normal in the late period of post 20-gauge vitrectomy. Artificial tears should be used to promote ocular surface recovery and relieve discomfort in early period after 20-gauge vitrectomy. (Ophthalmol CHN, 2015, 24: 336-340)

Key words:  vitrectomy, hypertension, stability of tear film