眼科

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正常人群视网膜血氧饱和度的测量

杨婧研 由冰 王倩 曾司彦 魏文斌   

  1. 100730 首都医科大学附属北京同仁医院 北京同仁眼科中心 眼科学与视觉科学北京市重点实验室 眼内肿瘤诊治研究北京市重点实验室
  • 收稿日期:2016-08-16 出版日期:2016-09-25 发布日期:2016-09-26
  • 通讯作者: 魏文斌, Email: weiwenbintr@163.com
  • 基金资助:

    北京市医院管理局“登峰”人才培养计划(DFL20150201);眼内肿瘤诊治研究北京市重点实验室2015年度科技创新基地培育与发展专项项目(Z151100001615052);国家自然科学基金(81570891);北京市医院管理局临床医学发展专项经费资助(扬帆计划)(ZYLX201307);国家自然科学基金(81272981);北京市自然科学基金(7151003);北京市卫生系统高层次卫生技术人才培养计划(2014-2-003)

Retinal vessel oxygen saturation in Chinese healthy individuals

YANG Jing-yan, YOU Bing, WANG Qian, ZENG Si-yan, WEI Wen-bin   

  1. Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
  • Received:2016-08-16 Online:2016-09-25 Published:2016-09-26
  • Contact: WEI Wen-bin, Email: weiwenbintr@163.com

摘要:

目的 测量正常人群中的视网膜血氧饱和度。设计 观察性横断面研究。研究对象 纳入的正常受试者91例,其中男性37例,女性54例,平均年龄(37.5±14.0)岁。方法 对所有受试者进行全身及眼科检查,并采用视网膜血氧仪(Oxymap)测量视网膜血氧饱和度。选取鼻上、鼻下、颞上及颞下象限来分别进行视网膜血氧含量的测量,测量范围为距视盘边缘0.5个直径至3个视盘直径之间,选取象限内最粗的动脉和静脉。将视网膜动、静脉血氧饱和度作为因变量,眼部参数及全身系统性参数作为自变量进行多因素线性回归,分析视网膜动、静脉血氧饱和度与全身因素及眼部指标之间的相关性。主要指标 视网膜平均动脉血氧饱和度(SaO2-A),视网膜平均静脉血氧饱和度(SaO2-V),视网膜平均动静脉血氧饱和度差值(SaO2-AV)。结果 中国正常人群的视网膜平均SaO2-A为(92.1±7.2)%;视网膜平均SaO2-V为(52.5±6.6)%;视网膜平均SaO2-AV为(39.6±7.5)%。鼻上象限的SaO2-A、SaO2-V和SaO2-AV较高,分别为(98.5±10.1)%、(57.3±8.7)%和(41.3±11.9)%。在多因素分析中,与SaO2-A相关的系统性因素包括高龄(B=0.24,P=0.049),高脂血症(B=0.26,P=0.018)。吸烟与SaO2-V的降低有一定的相关性(B=-0.25,P=0.033);SaO2-V与年龄(P=0.665)、眼压(P=0.073)、舒张压(P=0.616)无显著相关性。SaO2-AV与年龄呈正相关(B=0.219,P=0.046),与性别成负相关(B=-0.253,P=0.019)。结论 高龄人群的视网膜动脉血氧含量相对较高;吸烟可能会导致视网膜静脉血氧含量降低;视网膜动静脉血氧饱和度差值与年龄呈正相关;男性的视网膜动静脉血氧饱和度差值较大。(眼科,2016, 25: 339-342)

关键词: 视网膜血氧饱和度, 视网膜血氧仪

Abstract:

Objective To measure the normal retinal oxygen saturation (SaO2) values with retinal oximetry in healthy Chinese population. Design Observational cross-sectional study. Participants The study included 91 normal healthy subjects (mean age: 37.5±14.0 years;Male:37,Female:54). Method Healthy Chinese volunteers underwent systematic and ophthalmic examinations. Retinal oxygen saturation was examined by a noninvasive retinal oximeter. Main Outcome Measures The mean retinal arterial oxygen saturation (SaO2-A); the mean retinal venous oxygen saturation (SaO2-V); the mean retinal arteriovenous difference in oxygen saturation (SaO2-AV). Results The mean SaO2-A was 92.1±7.2%; the mean SaO2-V was 52.5±6.6%; the mean SaO2-AV was 39.6±7.5%. The mean SaO2-A(98.5±10.1%), SaO2-V(57.3±8.7%) and SaO2-AV(41.3±11.9%) were significantly higher in the superior nasal quadrant. Age was associated with increased SaO2-A (B=0.24, P=0.049) and SaO2-AV (B=0.219, P=0.046). Smoking was associated with decreased SaO2-V (B=-0.25, P=0.033). Hyperlipidemia was associated with increased SaO2-A (B=0.26, P=0.018). Male was associated with an increase in SaO2-AV(B=-0.253, P=0.019). Conclusions Aging may increase SaO2-A and SaO2-AV, whereas smoking may cause decreased SaO2-V. Male are likely to have higher SaO2-AV. (Ophthalmol CHN, 2016, 25: 339-342)

Key words: retinal oxygen saturation, retinal oximetry