关键词: 敷贴放射治疗, 葡萄膜肿瘤, 肿瘤转移, 放射性碘1 25, 安全性, 有效性

Abstract:

Objective To observe the safety and efficacy of domestic radioactive plaque for treatment of uveal metastasis. Design Retrospective case series. Participants 16 patients of uveal metastasis that were treated with domestic radioactive plaque in Beijing Tongren Hospital from October 2015 to March 2018. Methods We recorded data of visual acuity(VA), intraocular pressure (IOP), size of the tumor (maximum base diameter, maximum height) measured by CDI, changes in the subretinal fluid observed by indirect ophthalmoscope, CDI and OCT, and the data were retrospectively analyzed using SPSS 22.0. Main Outcome Measures VA, IOP, size of the tumor, changes in the subretinal fluid, occurrence rates of complications. Results  The surgery was performed smoothly in all 16 cases, without active hemorrhage, injury of extraocular muscle or vortex vein occurred during the operation, and no infection or scleral melting happened after the surgery. 14 patients received at least one follow-up. There was no statistical difference between preoperative and latest follow-up in either VA (pre-operation 0.24±0.29 versus latest follow-up 0.21±0.26, P=0.69) or IOP (pre-operation 13.3±5.8 mmHg versus latest follow-up 16.0±12.9 mmHg, P=0.39). Tumor regressed in all cases (maximum basal diameter: pre-operation 14.9±2.6 mm versus latest follow-up 9.9±3.9 mm, P<0.001; maximum height: pre-operation 6.3±1.9 mm versus latest follow-up 2.4±1.3 mm, P<0.001), and no subretinal fluid was observed by indirect ophthalmoscope, CDI and OCT at the latest follow-up. Conclusion The domestic radioactive plaque is safe and effective in treatment of uveal metastasis. (Ophthalmol CHN, 2018, 27: 388-391)

Key words: plaque radiotherapy, uveal tumor, tumor metastasis, Iodine125, safety, efficacy