关键词: 鳞状细胞癌, 眼睑, 组织病理学, TNM分期

Abstract:

Objective To analyze the clinical and histopathologic features and the factors associated with prognosis of the eyelid squamous cell carcinoma. Design Retrospective case series. Participants Forty-two cases of eyelid squamous cell carcinoma during January 2000 and March 2011 in Anyang Ophthalmology Hospital. Methods According to the initial records and follow-up feedback,  the clinical and histopathologic features were analyzed. The related factor of recurrence was analyzed by COX regression, and survival analysis using kaplan-meier method. The postoperative patients were followed-up for (45.7±9.87) months. Main Outcome Measures Age,  gender,  disease course,  disease region,  T classification,  pathological grade,  treatment methods. Results The age of 42 cases varied from 36 to 81 years old,  and the mean age was 61.9±7.82 years old. There were 24(57.1%) males and 18(42.9%) females. The tumors mainly located at the lower eyelid. The sample included four T1,  seven T2,  seventeen T3,  and fourteen T4 cases. The statistics analysis showed the length of the disease duration and the T classification were significantly associated with local recurrence(P＜0.05). The disease duration and the T classification were two risk factors for tumor recurrence. And the T classification was correlated with the five-year survival rate, the higher grade of T classification, the higher tumor-related mortality (r=8.818, P=0.035). Conclusion The clinical outcome of the eyelid squamous cell carcinoma is related with the length of the disease duration and the T classification of the tumor. The longer disease duration or the higher T classification,  predicted a higher recurrence rate of tumor. And the mortality rate increased with the higher T classification.（Ophthalmol CHN,  2018, 27：99-102）

Key words: squamous cell carcinoma, eyelid, histopathology, TNM stage