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相干光断层扫描血管成像对病理性近视脉络膜新生血管诊断价值的研究

莫静  曾司彦  周海英  李志华  魏文斌   

  1. 100730首都医科大学附属北京同仁医院 北京同仁眼科中心 眼科学与视觉科学北京市重点实验室 眼内肿瘤诊治研究北京市重点实验室(莫静、周海英、李志华、魏文斌);北京大学第三医院眼科中心 眼部神经损伤的重建保护与康复北京市重点实验室(曾司彦)
      
  • 收稿日期:2019-06-22 出版日期:2019-07-25 发布日期:2019-07-30
  • 通讯作者: 魏文斌,Email:weiwenbintr@163.com
  • 基金资助:

    北京市医院管理局临床医学发展专项经费(扬帆计划)(zYLx201307);北京市卫生系统高层次卫生技术人才培养计划(2014.2.003)

The application of optical coherence tomography angiography in assessment of choroidal neovascularization secondary to pathologic myopia 

MO Jing1, ZENG Si-yan2, ZHOU Hai-ying1 , LI Zhi-hua1, WEI Wen-bin1.   

  1. 1. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing 100730, China; 2. Department of Ophthalmology, Peking University Third Hospital. Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing 100191, China
  • Received:2019-06-22 Online:2019-07-25 Published:2019-07-30
  • Contact: WEI Wen-bin, Email: weiwenbintr@163.com

摘要:

目的 研究相干光断层扫描血管成像(optical coherence tomography angiography,OCTA)对病理性近视继发性脉络膜新生血管形成(choroidal neovascularization,CNV)的诊断价值。设计 诊断方法评价。研究对象 北京同仁医院眼科临床诊断的病理性近视CNV患者40例。方法 患者接受荧光素眼底血管造影(fundus fluorescein angiography,FFA)及OCTA检查。以FFA诊断为金标准,计算OCTA诊断病理性CNV的敏感性和特异性。采用Kappa检验评价OCTA与FFA对病理性近视CNV活动性判读的一致性。主要指标 敏感性、特异性、Kappa值。结果 OCTA诊断病理性近视CNV的敏感性为96.7%,特异性为100%。两种检查方法对病理性近视CNV活动性判读的一致性Kappa值为0.502(P<0.001),一致性程度中等。结论OCTA能够高敏感高特异性的判定病理性近视性CNV,但对病理性近视CNV活动性的判断与FFA一致性中等。(眼科,2019, 28: 265-268)

关键词: 相干光断层扫描血管成像, 病理性近视, 脉络膜新生血管

Abstract:

Objective To estimate the ability of OCTA in detecting choroiodal neovascularization (CNV) secondary to pathologic myopia and to assess the ability of OCTA in assessment of the activity of CNV compared to fundus fluorescein angiography (FFA). Design Diagnostic method evaluation. Participants 40 eyes with clinical diagnosis of CNV secondary to pathologic myopia in Beijing Tongren Eye Center. Methods All the eyes underwent FFA and OCTA respectively. The diagnosis of CNV and the judgment of CNV activity were compared between FFA and OCTA. Main Outcome Measures The sensitivity and specificity of OCTA, and Kappa value. Results The sensitivity and specificity of OCTA for choroidal neovascularization secondary to pathologic myopia were 96.7% and 100% respectively. The agreement for grading of CNV activity between OCTA and FFA was moderate (Kappa=0.502, P<0.001). Conclusion  OCTA demonstrate high sensitivity and specificity for detection of CNV secondary to pathological myopia, while with a moderate ability of grading CNV activity. (Ophthalmol CHN, 2019, 28: 265-268)

Key words: optical coherence tomography angiography, choroidal neovascularization, pathologic myopia