关键词: 睑缘炎相关性角结膜病变, 儿童

Abstract: Objective To observe the clinical features of blepharokeratoconjunctivitis (BKC) in children. Design Retrospectively case series. Participants Eighty-three BKC patients in Beijing Children's Hospital from November 2015 to November 2018. Methods General conditions, clinical symptoms, signs, misdiagnosis, therapeutic method and clinical efficacy were reviewed. All patients were treated with physical therapy such as meibomian gland massage and hot compress. Glucocorticoid eye drops were used in moderate and severe patients in the early stage. Main Outcome Measures Changes of eyelid, eyelid margin, conjunctiva and cornea, treatment results. Results The 83 BKC patients were aged from 1 to 11 years (median: 5.8years). There were 46 (55.42%) female patients. Most patients occurred in 3~6 years old (35, 42.17%). Ocular redness (67, 80.72%), photophobia, tearing and ocular pain (39, 46.99%), eye secretion (30, 36.14%) and rubbing (24, 28.91%) were the most common complain. The clinical signs were conjunctival hyperemia(83, 100%), papillary follicular hyperplasia (61, 73.49%), punctate epithelial infiltration (61, 73.49%), and neovascularization (45, 54.22%). The BKC had been misdiagnosed as keratitis (41, 49.4%), allergic conjunctivitis (22, 26.5%), bacterial conjunctivitis (12, 14.46%), chalazia (5, 6.02%), and viral conjunctivitis (3, 3.61%). The follow-up time was 3~25 months, average 7.3±3.6 months. There were 67 patients (80.72%) used glucocorticoid and physical therapy earlier achieved clinical recovery. Conclusion BKC in children often occur in 3~6 years old girls. The clinical symptoms are different. Whole course physical therapy combined with early use of glucocorticoid can significantly improve the efficacy. （Ophthalmol CHN, 2020, 29: 157-160）

Key words: blepharokeratoconjunctivitis, children