关键词:  , 选择性激光小梁成形术；原发性开角型青光眼；高眼压症

Abstract: Objective To study the effects of selective laser trabeculoplasty (SLT) on intraocular pressure (IOP) and number of glaucoma medications used in Chinese eyes. Design Retrospective case series. Participants 77 eyes of 65 patients with primary open-angle glaucoma (POAG, n=40) and ocular hypertension (OHT, n=37) were included. Among them, there were 34 males and 31 females with an average age of (49.63±18.91) years. Methods SLT were used as an adjuvant therapy (n=40) or as first-line treatment (n=37). Statistical analysis was performed on intraocular pressure(IOP) and the number of eye-drops used in different groups before surgery, 1 day, 1 week, 1 month, 3 months, 6 months, 12 months, and 36 months after surgery. Main Outcome Measures IOP and number of eye-drops used. Results As an adjuvant therapy, SLT was used to treat patients with POAG and OHT. The IOP before treatment was (22.63±2.15) mmHg in the POAG group and (23.48±1.83) mmHg in the OHT group; The IOP was significantly decreased at 1 day, 1 week, 1 month, and 3 months after treatment compared with that before surgery (all P<0.05). The average IOP was (17.97±4.22) mmHg in the POAG group and (19.61±3.19) mmHg in the OHT group; At 6, 12, and 36 months after treatment, the average IOP was (21.15±1.79) mmHg in the POAG group and (21.08±2.49) mmHg in the OHT group, and there was no significant difference in IOP before and after treatment (all P>0.05). Before treatment, average number of eye-drops used was (3.55±0.60) in the POAG group, and (2.94±0.73) in OHT group. After treatment, the average number of eye-drops used decreased to (2.49±0.62) (POAG group) and (2.13±0.73) (OHT group) after 36 months, which were lower than the baseline (all P<0.05). SLT used as first-line treatment, the IOP was (25.77±2.62) mmHg in POAG group, and (27.26±2.12) mmHg in OHT group before treatment. After treatment, the IOP of both groups at each time point was significantly lower than that before treatment (both P<0.05), with an average of (21.28±2.75) mmHg for the POAG group and (21.9±2.21) mmHg for the OHT group. Conclusion SLT has the same therapeutic effect on POAG and OHT. As an auxiliary treatment, SLT reduced IOP for only 3 months, meanwhile SLT reduced the number of glaucoma drugs used significantly. As first-line treatment, SLT provided a drop-free IOP control to patients for at least 36 months. (Ophthalmol CHN, 2025, 34: 102-107)

Key words: selective laser trabeculoplasty, primary open-angle glaucoma, ocular hypertension