眼科 ›› 2025, Vol. 34 ›› Issue (3): 227-231.doi: 10.13281/j.cnki.issn.1004-4469.2025.03.009

• 论著 • 上一篇    下一篇

局灶性脉络膜凹陷患者黄斑区视网膜微血管参数分析

刘宸琛  张丛  姚宁  刁莉莉  康立华  杨文利   

  1. 首都医科大学附属北京同仁医院 北京同仁眼科中心 眼科学与视觉科学北京市重点实验室,北京 100730
  • 收稿日期:2024-06-05 出版日期:2025-05-25 发布日期:2025-05-25
  • 通讯作者: 杨文利,Email:yangwl_tr@163 com

Analysis of macular retinal capillaries in focal choroidal excavation patients

Liu Chenchen, Zhang Cong, Yao Ning, Diao Lili, Kang Lihua, Yang Wenli   

  1. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing 100730, China
  • Received:2024-06-05 Online:2025-05-25 Published:2025-05-25
  • Contact: Yang Wenli, Email: yangwl_tr@163 com

摘要:  目的 应用相干光断层扫描血管成像(OCTA)观察局灶性脉络膜凹陷(FCE)患者黄斑区视网膜微血管特征。设计 病例对照研究。研究对象 2023年1月至2024年4月在北京同仁医院眼科收集的FCE患者26例(26眼)和同期健康体检者27例(27眼)。方法 应用OCTA检查测量患者黄斑中心凹无血管区(FAZ)面积、周长、血管密度(VD),中心凹区、旁中心凹区及中心凹周围区的VD。扫描范围为黄斑区6 mm×6 mm。采用独立样本t检验比较FCE患者与对照组各参数差异。主要指标 FAZ面积、周长、VD,中心凹区、旁中心凹区及中心凹周围区VD。结果 FCE患者FAZ区面积、周长、血管密度分别为(0.36±0.17)mm2、(2.31±0.53)mm、(53.74±6.22)%,与对照组的(0.32±0.11)mm2、(2.17±0.38)mm、(54.58±4.69)%比较,差异均无显著性意义(P=0.402、0.443、0.283)。FCE患者黄斑中心凹区、旁中心凹区及中心凹周围区浅层视网膜平均血管密度分别为(16.74±7.54)%、(51.15±4.79)%、(47.22±4.39)%,深层视网膜平均血管密度分别为(44.78±4.94)%、(37.08±9.49)%、(56.40±6.03)%,与对照组的浅层(18.35±6.57)%、(51.42±4.93)%、(50.04±5.47)%,深层(44.64±5.27)%、(34.13±8.17)%及(54.43±4.83)%比较,差异也均无显著性意义(P=0.303、0.467、0.363、0.482、0.248、0.212)。结论 FCE患眼黄斑区视网膜血管结构及内层视网膜血流灌注没有明显异常改变。(眼科,2025,34: 227-231)

关键词: 局灶性脉络膜凹陷, 相干光断层扫描血管成像, 血管密度

Abstract: Objective To assess the characteristics of the macular retinal capillaries in focal choroidal excavation (FCE) patients using optical coherence tomography angiography (OCTA). Design Case-control study. Participants From January 2023 to April 2024, 26 eyes of focal choroidal excavation patients diagnosed in Beijing Tongren Hospital and 27 healthy people of 27 eyes were included. Methods All subjects underwent OCTA examination with 6 mm×6 mm scans in the macular region, include the macular foveal avascular zone (FAZ) area, perimeter and vessel density (VD), as well as the VD of the foveal, parafoveal and perifoveal regions. The data from FCE eyes (study group) and the control eyes (control group) were compared using independent-samples t test. Main Outcome Measures FAZ area, perimeter and VD, the VD of the foveal, parafoveal and perifoveal regions. Results The FAZ area, perimeter and VD of study group were (0.36±0.17) mm2, (2.31±0.53) mm and (53.74±6.22)%. The FAZ area, perimeter and VD of control group were (0.32±0.11) mm2, (2.17±0.38) mm and (54.58±4.69)%. No significant differences were seen in FAZ area, perimeter and VD (P=0.402, 0.443, 0.283). The VD of the foveal, parafoveal and perifoveal regions in superficial retina of study group were(16.74±7.54)%,(51.15±4.79)% and(47.22±4.39)%. The VD of the foveal, parafoveal and perifoveal regions in deep retina of study group were(44.78±4.94)%,(37.08±9.49)% and(56.40±6.03)%. The VD of the foveal, parafoveal and perifoveal regions in superficial retina of control group were(18.35±6.57)%,(51.42±4.93)% and(50.04±5.47)%. The VD of the foveal, parafoveal and perifoveal regions in deep retina of control group were(44.64±5.27)%,(34.13±8.17)%and(54.43±4.83)%. No significant differences were seen in superficial and deep retinal VD between study and control group (P=0.303, 0.467, 0.363, 0.482, 0.248, 0.212). Conclusion There were no significant abnormalities in macular retinal vascular structure and inner retinal perfusion in focal choroidal excavation patients. (Ophthalmol CHN, 2025, 34: 227-231)

Key words:  focal choroidal excavation, optical coherence tomography angiography, vessel density