关键词: 眼表鳞状上皮瘤, 影像学特征

Abstract: Objective To explore the imaging, analysis ability and consistency of HR-OCT and AS-OCTA in ocular surface squamous epithelioma (OSSN) patients. Design Retrospective case series. Participants Seven OSSN patients who were admitted to Peking University Third Hospital from September 2017 to January 2021 were enrolled. Methods HR-OCT and AS-OCTA images were collected before and after treatment. HR-OCT and AS-OCTA results were interpreted by 3 senior ophthalmologists back-to-back under the same display and the intraclass correlation coefficient (ICC) was calculated to evaluate the reliability of measurement. Main Outcome Measures The characteristics of local lesions and their consistency measured by OCT and AS-OCTA before and after treatment. Results The clear boundary between the normal and abnormal epithelium, thickened hyperreflective epithelium, and the cutting plane between the lesion and the underlying tissue can be observed through HR-OCT. The inter-rater agreement coefficient for hyperreflective epithelial was 0.942 (95% CI： 0.805-0.989, P<0.001). After surgical resection of the tumor and local chemotherapy, the abnormal high reflection area in OCT can be found to disappear. AS-OCTA could clearly identify abnormal vessels, showing focal or scallop-like vessels at the lesion, part of the vessel branches into vein or terminal expansion to form a loop-like structure with an inter-rater agreement coefficient of 0.824 (P<0.001). After treatment, the abnormal vascular branches may be resolved or partially resolved, and patchy avascular areas may remain. In addition, HR-OCT and AS-OCTA are able to assess corneoconjunctival vascular abnormalities in patients with extensive invasion. Conclusions HR-OCT and AS-OCTA can be used to visualize OSSN lesions and vascular structural features with good agreement and are also suitable for patients with extensive invasion, which also the potentially powerful tools for non-invasive comprehensive assessment and objective monitoring of related vascular ocular surface diseases. (Ophthalmol CHN, 2023, 32: 120-126)

Key words:  ocular surface squamous epithelioma, imaging features