Abstract:  Objective To evaluate 1-year postsurgical safety and efficacy of canaloplasty for open-angle glaucoma (OAG) in adult patients. Design Retrospective case series. Participants 14 cases (17 eyes) of adult patients with OAG and with preoperative intraocular pressure (IOP) higher than 21 mmHg from Beijing Tongren Hospital in 2011-2012. Methods Canaloplasty was performed in all patients and evaluation was performed at baseline and 1, 3, 6, and 12 months postoperatively. Main Outcome Measures IOP, numbers of antiglaucoma medications and postoperative complications. Results The mean baseline IOP was 21.95±6.99 mmHg on a mean of 2.06±0.97 medications per patient. The mean IOP was 15.06±2.73 mmHg at 1 month, 15.34±2.53 mmHg at 3 months, 15.30±2.89 mmHg at 6 months and 15.23±2.64mmHg at 12 months  postoperatively(all P<0.05). Medication decreased to a mean of 0.59±1.12 per patient at 12 months (P=0.001). Surgical and postsurgical adverse events were reported in 12 eyes (79.60%) including hyphema (10 eyes), elevated IOP greater than 30 mmHg (1 eye), corneal stroma hemorrhage (1 eye), shallow anterior chamber (1 eye). All the complications were relieved after treatment. Conclusion Canaloplsty is a safe and effective surgical procedure to reduce IOP in adult patients with OAG. (Ophthalmol CHN, 2014, 23: 22-25， 36)

Key words: canaloplasty, open-angle glaucoma/surgery