Ophthalmology in China ›› 2022, Vol. 31 ›› Issue (1): 14-19.doi: 10.13281/j.cnki.issn.1004-4469.2022.01.003

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The preliminary study on long-term efficacy of penetrating canaloplasty in glaucoma 

Ye Wenqing, Gu Juan, Hu Cheng, Cheng Huanhuan, Deng Yuxuan, Zhang Shaodan, Xie Yanqian, Le Rongrong, Liang Yuanbo   

  1. The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Glaucoma Research Institute, Wenzhou Medical University; National Clinical Research Center for Ocular Diseases, Wenzhou 325027, China (Hu Cheng is now working at the Department of Ophthalmology, Wuhan General Hospital of PLA, Wuhan 430064, China; Cheng Huanhuan is now working at Wuhu First People’s Hospital, Wuhu 241060, China; Deng Yuxuan is now working at Qingdao Municipal Hospital, Qingdao 266011, China)
  • Received:2021-11-24 Online:2022-01-25 Published:2022-01-18
  • Contact: Liang Yuanbo, Email: yuanboliang@126.com
  • Supported by:
    National Key Research and Development Project (2020YFC2008200)； Zhejiang Province High-level Innovative Talents Plan of Heath (2016025)

Abstract:  Objective To evaluate the long-term efficacy and safety of penetrating canaloplasty for glaucoma. Design Retrospective case series. Participants Consecutive cases of 15 glaucoma patients (16 eyes) with penetrating canaloplasty at the Eye Hospital of Wenzhou Medical University from June 2015 to December 2015 were collected. Methods The preoperative demographic characteristics and postoperative intraocular pressure (IOP), glaucoma medications and other information were reviewed. Surgical success was defined as IOP ≤21 mmHg with or without glaucoma medications (qualified success) and without any glaucoma medications (completes success). Main Outcome Measures IOP, number of glaucoma medications, surgical success rate, complications and filtering bleb status. Results A total of 15 glaucoma patients (16 eyes) achieved the successful 360-degree catheterization of the canal with 7 males which were included to analyze. The mean age was (48.9±16.0) years old, and the mean preoperative IOP was (37.9±11.4) mmHg with the median medication number of 3 (2, 4). The mean postoperative IOP was (17.2±6.0), (15.9±4.5), (14.4±2.2), (13.0±1.8), (13.7±3.2), (12.9±2.9), (15.6±3.1), and (14.5±2.7) mmHg at 1 month, 3 months, 6 months, 12 months, 24 months, 36 months, 48 months, 60 months, respectively. There was significant difference in IOP between postoperative and preoperative. The median medication number (range) was 0 (0, 1.5) at 1 month and 0 at the rest follow-up time, respectively. There was significant difference in the number of medications between postoperative and preoperative. The complete success rate at 36 months and 60 months were both 81.3%. Intraoperative and postoperative complications were observed in 11 eyes (68.8%) of 16 eyes, mainly including IOP spike (43.8%) and hyphema (37.5%). 13 eyes (81.3%) had no obvious filtering bleb. Conclusions The penetrating canaloplasty is a new internal drainage surgery for glaucoma with stable long-term efficacy, but need to be observed in a larger sample. (Ophthalmol CHN, 2022, 31: 14-19)

Key words: glaucoma/surgery, penetrating canaloplasty