Abstract: Objective To investigate the feature of optic disc morphology in nonarteritic anterior ischemic neuropathy (NAION). Design Systemic review. Participants A comprehensive literature research was conducted for published studies reporting both optic disc morphology and NAION from CNKI, EMBASE and Pubmed database. Methods Based on inclusion and exclusion criteria, the study included data extraction and meta-analysis. Pooled WMD, heterogeneity and sensitivity analysis were calculated with Stata software. Main Outcome Measures Parameters of optic disc morphology. Results Between unaffected fellow eyes of NAION patients group and control group, the disc area (WMD=-0.20, 95%CI:-0.37~-0.03), cup area (WMD=-0.36, 95%CI:-0.58~-0.14), cup/disc area ratio (WMD=-0.15,  95%CI:-0.23~-0.06), cup volume (WMD=-0.08, 95%CI:-0.12~-0.05), mean cup depth (WMD=-0.10, 95%CI:-0.13~-0.06) and cup shape measure (WMD=-0.03, 95%CI:-0.05~-0.02) were smaller in the unaffected eyes, whereas there were no significant differences in rim area (WMD=0.05, 95%CI:-0.15~0.25) and rim volume (WMD=0.05, 95%CI:-0.07~0. 16). When the same parameters were compared between the affected and unaffected eyes of the patients with unilateral NAION, smaller rim volume (WMD=-0.08, 95%CI:-0.14~- 0. 02) and greater cup shape measure (WMD=0.03, 95%CI: 0.00~0.06) were in eyes after NAION, while the other optic disc parameters showed no correlations. Conclusion Small disc and small cup is the characteristic feature in the NAION, and after NAION there is a trend toward cupping compared with the fellow eye. (Ophthalmol CHN, 2014, 23: 235-239) 

Key words: nonarteritic anterior ischemic optic neuropathy, optic disc morphology, Meta-analysis