Abstract:

Objective  To assess the efficacy and safety of gatifloxacin and levofloxacin in treating bacterial conjunctivitis by conducting a meta-analysis. Design Systemic review. Participants Collected randomized clinical controlled studies (RCTs) of gatifloxacin versus levofloxacin in the treatment of bacterial conjunctivitis, which were retrieved from Chinese Biomedical Database, Chinese periodical full text database(CNKI), Wan-fang database, Database of Chinese Periodicals of Science and Technology, PubMed, Cochrane Library and Embase. Methods According to the inclusion and exclusion criteria, data extraction and quality assessment were done by two researchers independently, and clinically important measures were selected. Outcomes were pooled with Revman5.3 and Stata 12.0. Main Outcome Measures Curative ratio, healing rate, adverse reactions. Results The curative ratio (OR＝3.20, 95%CI=2.37~4.31, P＜0.00001) and healing rate (OR＝1.88, 95%CI=1.56~2.27, P＜0.00001) of gatifloxacin group was better than the levofloxacin, and tends to be less total adverse reactions (OR＝0.47, 95%CI=0.27~0.80, P=0.006). Eyes prick (OR＝0.76, 95%CI=0.37~1.57, P=0.46) and eye itch (OR＝0.32, 95%CI=0.10~1.00, P=0.05) were non-statistical significance among two groups. Conclusion In the treatments of bacterial conjunctivitis, gatifloxacin has better efficacy and safety with higher curative ratio and healing rate, and less adverse reactions.

Key words: gatifloxacin, levofloxacin, bacterial conjunctivitis, Meta-analysis