Abstract:

Objective To investigate the clinical features of scleroderma patients with ocular manifestations. Design Retrospective case series. Participants 13 scleroderma patients with ocular involvement were enrolled. Methods The clinical features, laboratory investigation and ocular manifestations of 13 cases of scleroderma with eye affected were retrospectively analyzed. Main Outcome Measures Ocular manifestations. Results All of the 13 cases were female with the mean age of (43±12.2 years). The mean disease duration of scleroderma was 6.1±5.1 years. The mean disease duration of eye involvement was 1.4±1.9 years. System sclerosis 11 cases(84.6%) and localized sclerosis 2 cases(15.4%) were included. Ocular manifestations in the 53.8% (7/13) cases were the primary manifestations. The most common ocular manifestations were kerato-conjunctivitis sicca 7 cases (53.8%), and skin change of the eyelid, glaucoma 3 cases for each(23.1%)，followed by optic neuritis，keratitis，anterior uveitis 2 cases for each（15.4%）; scleritis, cataract, uveitis, central serous chorioretinopathy, enophthalmos and dacryadenitis 1 case for each (7.7%). No association between ocular manifestation and clinical as well as laboratory findings was found. Conclusion Almost any part of the eye with diverse manifestation could be involved in any type of scleroderma. Kerato-conjunctivitis sicca is the most common ocular manifestation of scleroderma. (Ophthalmol CHN, 2015, 24: 317-319, 360)

Key words: scleroderma, autoimmune diseases, ocular manifestation