Abstract:

Objective To observe the characteristics of optic disc parameters and the change of peripapillary retinal nerve fiber layer (pRNFL) thickness in the patients with tuberculum sellae meningiomas. Design Retrospective case series. Participants The clinical data were collected in Tiantan Hospital from July 2010 to December 2011, which involved 40 patients (80 eyes) with tuberculum sellae meningiomas, 40 normal controls(80 eyes) and 40 glaucoma patients (80 eyes). Methods A total of 40 cases with tuberculum sellae meningiomas received the examination of fundus photography, pRNFL and optic disc parameters measurement by OCT, compared with the control group and glaucoma group. The relationship of optic disc parameters and tumor size were analysised. Describe the morphological characteristics of nuroretinal rim of optic discs (superior, S; nasal, N; inferior, I; temporal, T). Main Outcome Measures Rim volume, cup/disc（C/D） area ratio, horizontal C/D ration, vertical C/D ratio, rim area, cup area, cup volume and pRNFL. Results Optic disc parameters such as cup volume, optic disk area, C/D area ratio, horizontal C/D ratio, vertical C/D ratio, rim area, cup area in tumor group were bigger than in the normal group, rim volume were smaller than in the normal group (all P=0.000); C/D area ratio, horizontal C/D ratio, rim area, rim volume in the tumor group were bigger than in the glaucoma group, vertical C/D ratio, cup area, cup volume were smaller than in the glaucoma group (all P=0.000); The thickness of pRNFL in tumor group was 124.022±26.100 μm in ST, 105.856±23.410 μm in SN, 75.784±19.260 μm in NU, 65.983±15.708 μm in NL, 105.915±25.526 μm in IN, 133.591±24.429 μm in IT, 76.592±19.679 μm in TL, 77.352±26.100 μm in TU respectively, which were all significantly decreased compared with the thicknesses of pRNFL in normal group (all P<0.05). There was no significant differrence in SN (P=1.114) but significantly decreased in the other quadrants compared with the thicknesses of pRNFL in normal group (all P<0.05). The rim volume in tuberculum sellae meningioma evidently showed correlations with tumor size (r=0.492, P=0.000). Conclusion The features of optic disc parameters in the tuberculum sellae meningiomas shown as the temporal neuroretinal rim become narrow and pale;  compared with the normal control, the pRNFL thickness showed significant thiner in IN section; compared with glaucoma group, the except for SN region, other regions were significantly thiner, especially in IT section.

Key words: tuberculum sellae meningiomas, optic disc parameters, retinal nerve fiber layer, optical coherence tomography