Abstract: Objective To evaluate the detection of tear meniscus by OCT-RTVue and the relativity between the parameters of OCT-RTVue and the traditional diagnosis parameters in dry eye. Design Prospective case series. Participants Sixty-nine patients with dry eye and forty-four healthy age-and sex-matched control subjects were included from June to December 2015. Methods All subjects were underwent the examinations sequentially as follows: evaluation of ocular surface disease symptoms using the Ocular Surface Disease Index(OSDI), the examinations of OCT-RTVue, tear film interferometry, tear film break-up time (BUT), corneal and conjunctival staining (Oxford scale) and Schirmer I test. The parameters between dry eye group and the control group were compared. Spearmans correlation analysis was used to analyze the correlation of the parameters of dry eye group. Receiver operating characteristic curve (ROC curve) and area under the curve (AUC) were used to describe the accuracy of each parameter to differentiate dry eyes from normal eyes. Main Outcome Measures OSDI score, BUT, Schirmer I, the score about lipid layer of the tear film, conjunctival staining, tear meniscus height (TMH), tear meniscus depth (TMD), tear meniscus area (THA). Results OSDI score and conjunctival staining were obviously higher in dry eye group (49.03±22.791, 1.18±1.84) than those in control group (8.91±4.99, 0.24±0.52) (P<0.001, 0.016). BUT and Schirmer I value were significantly lower in dry eye group (4.32±1.92 s, 4.29±3.77 mm) than those in control group (7.43±5.39 s, 7.48 ±3.65 mm) (P<0.001, 0.006). According to the score about lipid layer of the tear film, there wasn't significant differences in the two group (P=0.223). TMD, TMH, TMA were significantly higher in dry eye group (127.12±86.95 μm, 152.52±125.15 μm, 12119 ± 1342 μm2) than those in control group (188.25 ± 87.38 μm, 235.41±135.90 μm, 23099±1965 μm2）(P<0.001, 0.001, 0.001). TMD, TMH, TMA were correlated with OSDI,  Schirmer I, BUT in dry eye group (all P<0.05). AUC value of TMD, TMH, TMA was 0.934, 0.89, 0.925 respectively. Conclusion The examinations OCT-RTVue can reflect accurately the tear meniscus height and depth and may have potential applications for the diagnosis and evaluation of dry eye.

Key words: dry eye; , optical coherence tomography, tear meniscus, sensitivity, specificity