Abstract: Objective To analyze the clinical characteristics and prognosis of cytomegalovirus retinitis with acquired immune deficiency syndrome without anticytomegalovirus therapy. Design Retrospective cases series. Particpants 11 patients with cytomegalovirus retinitis combined with acquired immune deficiency syndrome who had not been anticytomegalovirus. Methods Visual acuity, intraocular pressure, slit lamp, visual field and fundus examination were evaluated and observed during the follow-up for 2 months to 5 years (26.2±23.8 months). Main Outcome Measures Vision, anterior segment, fundus. Results In the 21 eyes of 11 patients with cytomegalovirus retinitis, 14 eyes were no light perception, two eyes had vision of less than 0.05, one eye had vision of no less than 0.05 and less than 0.3， only 4 eyes of them had vision no less than 0.3. Five eyes of 21 eyes had pigmented KP only, 16 of 21 eyes had cataracts, 13 of 21 eyes had anterior and posterior synechia, 3 eyes of 2 patients had keratopathy. 9 eyes which can be seen fundus had fundus scars, 2 of them had retina detachment. Conclusion Patients who have cytomegalovirus retinitis with acquired immune deficiency syndrome without anticytomegalovirus therapy will have poor visual prognosis, can cause the anterior segment lesions, in addition to the fundus lesions.

Key words: acquired immune deficiency syndrome, cytomegalovirus retinitis, antivirus therapy, prognosis