Ophthalmology in China

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Effective factors of one-year visual outcomes after intravitreal injection of ranibizumb for wet age-related macular degeneration

YAN Shu, SHAO Ling, DU Min, SHEN Ce-ying, LI Yan, LIU Yu, CHAO Yang-yang, YANG Kai-zhuan   

  1. Department of  Ophthalmology, Zhengzhou Second People Hospital, Zhengzhou 450006, China
  • Received:2018-05-17 Online:2019-11-25 Published:2019-12-06
  • Contact: YAN Shu, Email: yanshu8302@126.com E-mail:yanshu8302@126.com

Abstract:

Objective To investigate one-year visual outcomes after intravitreal injection of ranibizumb for wet age-related macular degeneration(wAMD) and its influencing factors. Design Retrospective case series. Participants  Fifty cases (50 eyes) of  wAMD  in Zhengzhou Second People Hospital form May 2015 to February 2017. Methods All subjects received  eye examination, including best corrected visual acuity (BCVA), funds color photography, fundus fluorescein angiography (FFA), optical coherence tomography (OCT) and OCT angiography(OCT-A). The scheme of intravitreal injection ranibizumb consisted of once a month for three month, followed by an PRN scheme. The one year BCVA  and the change of BCVA  from pretherapy to  post-treatment were observed. The correlation between the one year BCVA , improvement and baseline factors that include age, gender, baseline BCVA, macular subretinal hemorrhage, intraretinal fluid, subretina fluid, pigment epithelium detachment, central foveal thickness (CFT), area of  choroidal neovascularization (CNV),  type of CNV (predominantly classic, min classic and  latent ) were analyzed. Main Outcome Measures BCVA, macular subretinal hemorrhage, intraretinal fluid, subretina fluid, pigment epithelium detachment, CFT, area of CNV and the type of  CNV.  Results Before therapy , BCVA was (53.4±14.5) letters, and 1 year after therapy, BCVA was (61.3±20.5) letters, improvement letters was  (7.9±8.5) (t=-6.564, P<0.01). Multiple linear regression shows that baseline BCVA was opsitive associated with  BCVA outcomes at 1 year (B=0.483, P=0.001); area of  CNV  and type of CNV was  negative associated with  BCVA outcomes at 1 year ( B=-0.211, P=0.005; B=-0.202, P=0.005). That area of  CNV and type of CNV was negative associated with improved BCVA score at 1 year  (B=-0.509, P=0.005; B=-0.488, P=0.005). BCVA outcomes of 1 year of predominantly classic CNV was worst and latent was best, the improved BCVA at 1 year of predominantly classic CNV was least and  min classic CNV was most (P<0.05). Conclusion Predominantly classic CNV and  bigger area of CNV have little improvement of one-year BCVA and poor prognosis. People who with better baseline BCVA will have better BCVA at one year.

Key words: wet age-related macular degeneration, ranibizumb, visual acuity