Ophthalmology in China ›› 2021, Vol. 30 ›› Issue (4): 259-264.doi: 10.13281/j.cnki.issn.1004-4469.2021.04.002

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Anterior chamber volume measurement and its value of screening primary angle-closure glaucoma in adults over 45 years old: The Beijing Eye Study

Chen Changxi, Wang Jinda, Cao Kai, Xu Liang, Wang Yaxing, Li Jianjun    

  1. Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Key Laboratory of Beijing Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China

  • Received:2021-04-12 Online:2021-07-25 Published:2021-07-22
  • Contact: Li Jianjun, Email: jianjunli2005@163.com
  • Supported by:
    Pilot Project of Public Welfare Development and Reform of Beijing Municipal Medical Reasearch Institutes (2019-4)

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Abstract: Objective To study the measurement results of anterior chamber volume (ACV) in adults over 45 years and its screening value for primary angle closure glaucoma (PACG). Design Cross-sectional survey. Participants 3251 subjects in the Beijing Eye Study 2006. Methods  Heidelberg anterior segment optical coherence tomography (AS-OCT) was used to measure the subjects' ACV and other anterior segment parameters. The subjects were divided into different groups according to their refractive status and age for analysis. Spearman rank correlation analysis was used to explore the correlation between ACV and other anterior segment parameters. Receiver operating characteristic curve (ROC) was used to evaluate the value of ACV and other anterior segment parameters in PACG screening. Delong's test was used for comparison of multiple ROC curves. Logistic regression was used to explore the influencing factors of PACG. Main Measure Outcomes ACV, area under the ROC curve. Results The average ACV level of subjects over 45 years old was 132.07±32.66 mm3. The average level of ACV in men was 139.77±33.15 mm3, and  126.15±31.00 mm3 in women. The average ACV level of subjects aged 45~54, 55~64, 65~74 and ≥75 years old was 143.23±31.25 mm3, 129.71±32.65 mm3, 123.71±30.56 mm3 and 115.71±28.92 mm3, respectively. The average ACV levels of myopia, hyperopia subjects were 149.86±37.34 mm3 and 113.39±26.84 mm3. For subjects with PACG, the average ACV level was 79.15±13.63 mm3. When screening PACG, the area under the ROC curve of ACV, anterior chamber depth (ACD), 500  μm anterior chamber angle (ACA) is 0.938, 0.937, 0.938, respectively.  According to Youden index, the cut-off value of using ACV to screen PACG is 114.90 mm3. Conclusion The average ACV level of people over 45 years old in Beijing area is 132.07±32.66 mm3. ACV gradually decreases with age. ACV of myopia population is larger. The ability of ACV to screen PACG is not weaker than that of ACA and ACD.  ACV with lower than 115 mm3 indicates the higher risk of PACG. (Ophthalmol CHN, 2021, 30: 259-264)

Key words: anterior chamber volume, angle-closure glaucoma, screening efficacy, cross-sectional study