Table of Content

25 July 2021, Volume 30 Issue 4

Previous Issue   

Clinical evidenced guideline for treatment of retinitis pigmentosa

Chinese Eye Genetics Consortium, Chinese Team for Clinical Diagnosis and Treatment of Genetic Eye Diseases, Genetic Eye Disease Group, Ophthalmologist Branch, Chinese Medical Doctor Association

2021, 30(4):  249-258.  doi:10.13281/j.cnki.issn.1004-4469.2021.04.001

Asbtract ( 1523 )   PDF (1310KB) ( 6282 )  

Related Articles | Metrics

Retinitis pigmentosa (RP) is the most common hereditary retinal disease. There are many reports on the treatment of RP, including the drugs, laser, surgical, gene and cell therapy. The effectiveness of previous treatments is ambiguous. The emerging gene therapy and cell therapy for RP have shown safety and worth further investigations and randomized clinical trials. In addition, there are some problems in the treatment of RP combined with cataract and other ocular complications. This guideline summarizes treatments of RP and its complications, refers to the latest literatures, and extensively solicits opinions from experts for the reference of ophthalmologists. (Ophthalmol CHN, 2021, 30: 249-258)





Anterior chamber volume measurement and its value of screening primary angle-closure glaucoma in adults over 45 years old: The Beijing Eye Study

Chen Changxi, Wang Jinda, Cao Kai, Xu Liang, Wang Yaxing, Li Jianjun

2021, 30(4):  259-264.  doi:10.13281/j.cnki.issn.1004-4469.2021.04.002

Asbtract ( 320 )   PDF (2061KB) ( 5853 )  

Related Articles | Metrics

Objective To study the measurement results of anterior chamber volume (ACV) in adults over 45 years and its screening value for primary angle closure glaucoma (PACG). Design Cross-sectional survey. Participants 3251 subjects in the Beijing Eye Study 2006. Methods  Heidelberg anterior segment optical coherence tomography (AS-OCT) was used to measure the subjects' ACV and other anterior segment parameters. The subjects were divided into different groups according to their refractive status and age for analysis. Spearman rank correlation analysis was used to explore the correlation between ACV and other anterior segment parameters. Receiver operating characteristic curve (ROC) was used to evaluate the value of ACV and other anterior segment parameters in PACG screening. Delong's test was used for comparison of multiple ROC curves. Logistic regression was used to explore the influencing factors of PACG. Main Measure Outcomes ACV, area under the ROC curve. Results The average ACV level of subjects over 45 years old was 132.07±32.66 mm3. The average level of ACV in men was 139.77±33.15 mm3, and  126.15±31.00 mm3 in women. The average ACV level of subjects aged 45~54, 55~64, 65~74 and ≥75 years old was 143.23±31.25 mm3, 129.71±32.65 mm3, 123.71±30.56 mm3 and 115.71±28.92 mm3, respectively. The average ACV levels of myopia, hyperopia subjects were 149.86±37.34 mm3 and 113.39±26.84 mm3. For subjects with PACG, the average ACV level was 79.15±13.63 mm3. When screening PACG, the area under the ROC curve of ACV, anterior chamber depth (ACD), 500  μm anterior chamber angle (ACA) is 0.938, 0.937, 0.938, respectively.  According to Youden index, the cut-off value of using ACV to screen PACG is 114.90 mm3. Conclusion The average ACV level of people over 45 years old in Beijing area is 132.07±32.66 mm3. ACV gradually decreases with age. ACV of myopia population is larger. The ability of ACV to screen PACG is not weaker than that of ACA and ACD.  ACV with lower than 115 mm3 indicates the higher risk of PACG. (Ophthalmol CHN, 2021, 30: 259-264)

Biometric characteristics of primary angle closure glaucoma with zonular abnormality found during cataract surgery

Pei Xueting, Fan Zhigang, Qing Guoping, Li Dongjun, Wang Shuhua

2021, 30(4):  264-269.  doi:10.13281/j.cnki.issn.1004-4469.2021.04.003

Asbtract ( 327 )  

Related Articles | Metrics

 Objective To observe the characteristics of ocular parameters in primary angle closure glaucoma (PACG) combined cataract patients with zonular abnormality found during cataract surgery. Design Retrospective comparative case series. Participants Patients with PACG who underwent cataract surgery from May, 2019 to December, 2020 at Beijing Tongren Hospital were reviewed, which include 45 PACG eyes with zonular abnormality found during cataract surgery(zonular abnormality group), 95 PACG eyes without zonular abnormality, and 41 eyes with secondary angle closure glaucoma induced by lens subluxation (SACG-LS). Methods Medical records of all patients were reviewed, including ocular parameters measured using IOL master and UBM.  Main Outcome Measures Anterior chamber depth (ACD), lens vault (LV), lens thickness (LT), and axial length (AL).  Results There was no statistically significant difference in AL [(22.07±0.78) mm vs (22.20±0.75) mm, P=0.650] and ACD [(1.61±0.31) mm vs (1.74±0.35) mm, P=0.074] between zonular abnormality group and without zonular abnormality group. LV was 1.41±0.35 mm in zonular abnormality group, 1.04±0.21 mm in without zonular abnormality group, and 1.73±0.45 mm in SACG-LS group. The LV differences between every two groups reached statistical significance (all P=0.000). The LV inter-eye difference reached statistical significance [(1.42±0.25) mm vs (1.24±0.27) mm, P=0.049] in zonular abnormality group. LT showed no statistical significance between zonular abnormality group and SACG-LS group [(5.14±0.26) mm vs (5.18±0.29) mm, P=0.808], and thicker than without zonular abnormality group. 80% patients of zonular abnormality group showed LV higher than 1.2 mm as well as LT thicker than 4.9 mm. Conclusion It is probability that the zonule may be abnormal in PACG patients with preoperative LV higher than 1.2 mm as well as LT thicker than 4.9 mm. (Ophthalmol CHN, 2021, 30: 264-269)





Analysis of early stage of corneal epithelial remodeling after SMILE for moderate and high myopia

Zhang Qiulu, Song Yanzheng, Fu Caiyun, Zhai Changbin

2021, 30(4):  270-274.  doi:10.13281/j.cnki.issn.1004-4469.2021.04.004

Asbtract ( 379 )  

Related Articles | Metrics

 Objective To analyze the characteristics of early corneal epithelial thickness changes after femtosecond laser small incision corneal stromal lens extraction (SMILE) with anterior segment OCT. Design Retrospective case series. Participants 70 patients (140 eyes) with mean age (27.03±5.55) years old of moderate or high myopia and myopic astigmatism were underwent SMILE surgery from May to August 2020 by a single surgeon in Beijing Tongren Hospital. Method The patients’ medical records were reviewed, including the preoperative refractive diopter, preoperative and postoperative corneal epithelial thickness by anterior segment OCT. Main Outcome Measures Preoperative refraction diopter, Ks, Kf value of the cornea anterior surface and the central corneal thickness(CCT). The corneal epithelial thicknesses of 0-2 mm in the center of the cornea, the superior (S), inferior (I), nasal (N), temporal (T), superior-nasal (SN), superior-temporal (ST), inferior-nasal (IN) and inferior-temporal (IT) positions within the range of 2-5 mm and 5-6 mm before and 1 month after the operation. Results At 1 month after SMILE, the corneal epithelial of moderate myopia group had statistically significant thickening (all P<0.05) at 0-2 mm (t=3.956); 2-5 mm S (t=5.898), I (t=7.333), T (t=8.011), IN (t=3.878), ST (t=5.803), IT (t=9.160); and 5-6 mm I (t=4.668), T (t=7.470), IN (t=2.285), ST (t=5.389) and IT (t=6.805) compared with preoperation. And the corneal epithelialum of high myopia group had statistically significant thickening (all P<0.05) at all locations compared with preoperation [0-2 mm（t=6.144）; 2-5 mm（tS=7.770, tI=7.399, tN=5.294, tT=8.902, tSN=5.599, tIN=6.413, tST=7.628, tIT=8.055）; 5-6 mm（tS=3.373, tI=2.927, tN=5.373, tT=5.847, tSN=3.770, tIN=4.166, tST=4.826，tIT=4.219）]. Conclusion At 1 month after SMILE, the corneal epithelium thickness increased unevenly in the high myopia group, especially in the temporal and inferiorside. The corneal epithelium thickened much more in high myopia group than moderate myopia group. The central corneal epithelial thickness increment was negatively correlated with preoperative SE and postoperative corneal Km, and positively correlated with intraoperative corneal ablation depth. (Ophthalmol CHN, 2021, 30: 270-274)





Effect of cefuroxime sodium anterior chamber injection on corneal endothelium

Guo Zuofeng, Zhou Yanwen

2021, 30(4):  275-278.  doi:10.13281/j.cnki.issn.1004-4469.2021.04.005

Asbtract ( 327 )  

Related Articles | Metrics

Objective To observe the effect of cefuroxime sodium anterior chamber injection on corneal endothelial cells. Design Prospective comparative case series. Participants 100 eyes of 100 patients with age-related cataract who underwent phacoemulsification. Methods Randomly divided into two groups. 50 eyes of 50 cases in the experimental group were injected with cefuroxime sodium 1mg (0.1 ml) into the anterior chamber at the end of phacoemulsification, and 50 eyes of 50 cases in the control group were injected with 0.1 ml of compound sodium chloride solution in the anterior chamber. Both groups of patients were operated by the same surgeon, the same phacoemulsification equipment and the same parameters. Corneal endothelial cell density (CD), corneal endothelial hexagonal cells (HEX), central corneal thickness (CCT) were compared between the two groups at one month after the surgery. Main Outcome Measures CD, HEX, CCT. Results The preoperative CD of the experimental group and the control group were (2472.23±312.24) and (2534.12±324.58)/mm2 (P>0.05), respectively, and the CD at 1 month after surgery were (2338.32±356.89) and (2456.12±375.23/mm2) (P>0.05); the HEX of the experimental group and the control group were (69.21±12.51%) and (73.24±15.68%) (P>0.05) before the operation, and the HEX at 1 month after the operation was respectively (62.82±14.61%), (60.19±16.37%) (P>0.05); the preoperative CCT of the experimental group and the control group were (535.26±34.25) and (527.89±31.11) μm (P>0.05), respectively. The CCT at 1 month was (579.4±24.6) and (571.3±31.2) μm (P>0.05). Conclusion Phacoemulsification for cataract combined with 1 mg cefuroxime sodium injection in the anterior chamber has no significant effect on the count and morphology of corneal endothelial cells. (Ophthalmol CHN, 2021, 30: 275-278)





Analysis of clinical characteristics of 12 cases of scleral penetration caused by retrobulbar anesthesia

Zeng Rui, Yang Jiasong, , Li Yunpeng, Li Honghui, Li Wensheng,

2021, 30(4):  278-282.  doi:10.13281/j.cnki.issn.1004-4469.2021.04.006

Asbtract ( 397 )  

Related Articles | Metrics

Objective To summarize the clinical characteristics and management of scleral perforation during retrobulbar anesthesia. Design Retrospective case series. Paticipants 12 cases of scleral perforation during retrobulbar anesthesia were enrolled from 2012 to 2019. Methods Patient’s medical records were reviewed. The follow-up period of 12 patients was 9.5±5.4 months. Main Outcome Measures Age, gender, medical history, clinical manifestations, intraoperative conditions, and postoperative follow-up results. Results The average age of 12 patients was (54.9 ±7.8) years, including 8 females. There were 11 patients with high myopia. The operations to be performed under retrobulbar anesthesia were vitrectomy for rhegmatogenous retinal detachment in 8 cases, silicone oil removal in 2 cases, silicone oil removal combined with phacoemulsification in 1 case, and vitrectomy combined with phacoemulsification in 1 case of myopic foveoschisis. Eyeball perforation was found in time during the operation. All patients with rhegmatogenous retinal detachment were tamponaded with silicone oil after scleral perforation was found. In addition, patients with silicone oil removal and myopic foveoschisis were tamponaded with air at the end of the operation. The treatment of scleral penetration was laser photocoagulation of the retina after the removal of hemorrhage beneath or above the retina, silicone oil tamponaded in the case with retinal detachment, and disinfection air tamponaded in the case with no retinal detachment. At the last follow-up, the best corrected visual acuity was from HM to 0.6, and was improved compared with before surgery in 10 cases. Among the 12 patients, 7 of 8 patients with rhegmatogenous retinal detachment underwent vitrectomy combined with silicone oil filling, and no retinal detachment was found after silicone oil removal. In one case of high myopia, the posterior retina was not reattached and the silicone oil could not be removed. Conclusions The complications of eyeball penetration caused by retrobulbar anesthesia can cause serious eye damage, which can be minimized by timely and appropriate treatment. (Ophthalmol CHN, 2021, 30: 278-282)





Incidence and influencing factors of anterior chamber reaction after intravitreal injection of ranibizumab and conbercept

Zhang Xifang, Chen Rui, Miao Jingpeng, Qi Yue, Deng Guangda, Yang Fan, She Haicheng

2021, 30(4):  283-289.  doi:10.13281/j.cnki.issn.1004-4469.2021.04.007

Asbtract ( 761 )  

Related Articles | Metrics

 Objective To compare the incidence of positive anterior chamber reaction after intravitreal injection of ranibizumab and conbercept, and analyzing the influencing factors. Design Prospective cohort study. Participants 877 patients received intravitreal injection of ranibizumab or conbercept in the day care unit of Fundus Department of Beijing Tongren Hospital between January 2020 and October 2020. Methods Intravitreal injection was performed according to the unified operation standard. At the first day after operation, the patients were examined and recorded for pain, blurred vision. Slit lamp examination was conducted to observe the ciliary congestion, anterior chamber cells, aqueous flare and hypopyon. Anterior chamber cells and aqueous flare were recorded according to the scheme determined by the standardized uveitis nomenclature (SUN) working group. Anterior chamber reaction was recognized as positive if anterior chamber cell or aqueous flare> 0 and following treatment were recorded. The incidence of positive reaction in ranibizumab and conbercept injection groups was compared, and its influencing factors were analyzed by generalized additive mixed model (GAMM). Main Outcome Measures Incidence of anterior chamber reaction and its risk factors. Results There were 418 males and 459 females with an average age of 60.8 ± 14.4 years (range, 11~92 years). The average injection times per person were 2（1~3）, and the total number of injections was 1148.  Among the 1148 intravitreal injections, 27 eyes (27 patients) had positive anterior chamber reaction. The anterior chamber cell grade was 0.5+~2+, and the aqueous humor flash grade was 1+~2+. The incidence of positive anterior chamber reaction after ranibizumab or conbercept intravitreal injection was 2.5% (18/721 injection) and 2.1% (9/427 injection), respectively. There was no significant difference between the two groups (χ2=0.176, P=0.674). No patients had complaints of eye pain or vision loss, and no ciliary hyperemia or hyphema was detected. All patients were followed up without additional treatment except one case, for whom prednisolone acetate eye drops were prescribed. Multivariate regression analysis showed that the incidence of positive anterior chamber reaction decreased with the increase of injection times (OR=0.48, 95%CI: 0.26~0.88, P=0.0179), and the risk of anterior chamber reaction increased by 8.27 times (P＜0.001) and 9.6 times (P＜0.001) in patients with vitreous hemorrhage or neovascular glaucoma, respectively. There was no correlation with age, gender, eye laterality and diagnosis (P>0.05). Conclusion The incidence of positive anterior chamber reaction after intravitreal injection of ranibizumab and conbercept was 2.5% and 2.1%, respectively. The patients with vitreous hemorrhage, neovascular glaucoma and the first-time injection were prone to positive anterior chamber reaction. (Ophthalmol CHN, 2021, 30: 283-289)





Clinical characteristics of endogenous endophthalmitis in patients with acquired immunodeficiency syndrome

Liu Xiyao, Mao Feifei, Li Dan, Lu Dan, Wang Shengnan, Sun Huiyu

2021, 30(4):  290-294.  doi:10.13281/j.cnki.issn.1004-4469.2021.04.008

Asbtract ( 329 )  

Related Articles | Metrics

Objective To investigate the clinical characteristics of endogenous endophthalmitis in patients with acquired immunodeficiency syndrome. Design Retrospective case series. Participants 12 patients (15 eyes) with acquired immunodeficiency syndrome diagnosed with endogenous endophthalmitis in Beijing Ditan Hospital from 2014 to 2020. Methods The medical records of the patients were reviewed. Aqueous fluid tests include bacterial culture, fungal culture and detection of non-cultured suppurative pathogens or metagenomics next generation sequencing. Vitreous injection and/or vitrectomy were performed to treat. Main Outcome Measure Visual acuity, anterior segment and fundus manifestations, and aqueous humor test. Results All the 12 cases were male with an average age of 41.83±8.50 years. There were 4 cases of pulmonary tuberculosis, 5 cases of syphilis, 3 cases of cryptococcal meningitis, 3 cases (4 eyes) of cytomegalovirus retinitis, and 4 cases of fever. 6 eye had fungal endophthalmitis. 9 eye had bacterial endophthalmitis (staphylococcus aureus in 2 eyes, staphylococcus epidermidis in 1 eye, streptococcus in 1 eye, escherichia coli in 2 eyes, bradylosis streptococcus in 1 eye, haemophilus influenzae in 1 eye, sphingomonas paucimobilis in 1 eye). 7 eyes were complicated with virus infection (varicella zoster virus in 2 eyes, cytomegalovirus in 4 eyes, EB virus in 1 eye). Vitreous injections were performed in 14 eyes and vitrectomy was performed in 4 eyes. Endophthalmitis was controlled in 14 eyes, and 1 eye ruptured. Conclusion Early diagnosis and treatment of endogenous endophthalmitis with acquired immunodeficiency syndrome can control infection. The detection efficiency can be improved by bacterial culture and fungal culture in the intraocular fluid, combined with the detection technology of non-cultured pathogens. Attention should be paid to the presence of virus infection in these patinets. (Ophthalmol CHN, 2021, 30: 290-294)





Clinicopathological analysis of 12 cases of intraocular lymphoma

Zhang Xu, Xu Xiaolin, Li Bin, Peng Xiaoyan, Gao Fei, Zhang Zhibao

2021, 30(4):  295-299.  doi:10.13281/j.cnki.issn.1004-4469.2021.04.009

Asbtract ( 370 )  

Related Articles | Metrics

Objective To investigate the clinicopathological features and prognosis of intraocular lymphoma. Design Retrospective case series. Participants 12 cases of enucleation patients with intraocular lymphoma diagnosed from 2012 to 2019. Methods Clinical features, histopathological morphology and prognosis in medical records were reviewed. Main Outcome Measures Tumor site, pathological classification and prognosis. Results There were 7 males in 12 cases. Mean age was 58.2±10.9 years. None of the patients had a history of lymphoma in other parts of the body. The most common presentation was visual acuity loss (11/12), with a mean course of 12.6±10.3 months. The most common site of intraocular lymphoma was choroid (9/12), in which the retina was involved in 1 case (1/9) , iris and ciliary body were involved in 6 cases (6/9). Only 1 case (1/12) was located in both the ciliary body and the iris. Only the retina involved was found in 2 cases (2/12). The pathologic classification of primary choroidal lymphoma was mainly diffuse large B-cell lymphoma (DLBCL) (5/9), followed by mucosa-associated lymphoid tissue marginal B-cell lymphoma (MALT) (3/9). 1 case of primary iridociliary body lymphoma was DLBCL. 2 cases of primary retinal lymphoma were DLBCL. Extraocular diffusion occurred in 4 patients, 3 with MALT and 1 with mantle cell lymphoma (MCL). Both of the 2 patients with central nervous metastasis were DLBCL. All cases were followed up for 11-99 months. All the DLBCL patients received systemic chemotherapy with methotrexate drug after enucleation. All the 6 patients with tumors located in the choroid and iridociliary body were survived, and 1 of the 2 patients with tumors located only in the retina died and 1 was lost to follow-up. None of the 3 MALT patients with tumors located in choroid received systemic chemotherapy, and all of them have survived without disease at present. Of the 2 DLBCL patients with central nerve metastasis, 1 patient with whole uveal and retinal involvement survived after systemic chemotherapy, while 1 patient with retinal involvement only died after chemotherapy. Conclusion Choroidal lymphoma was the most common intraocular lymphoma. DLBCL was the most common pathological type, followed by MALT.  The survival prognosis of choroidal DLBCL patients after systemic chemotherapy was good. Choroidal MALT patients are prone to extraocular metastasis, and the survival prognosis is good despite no postoperative chemotherapy. All retinal lymphomas are DLBCL with poor survival and prognosis. (Ophthalmol CHN, 2021, 30: 295-299)





Clinical characteristics and treatment of children orbital Langerhans cell histiocytosis

Zhang Shaobo, Wang Ping, Cheng Qilin, Zhang Qiong, Ning Xiaona, Li Yangjun

2021, 30(4):  300-306.  doi:10.13281/j.cnki.issn.1004-4469.2021.04.010

Asbtract ( 432 )  

Related Articles | Metrics

Objective  To investigate the clinical features and treatment of children orbital Langerhans cell histiocytosis (LCH). Design Retrospective case series. Participants  From April 2013 to May 2019, 7 patients (8 eyes) with orbital LCH were confirmed in the Second Affiliated Hospital of Air Force Military Medical University. Method The general  situation, clinical manifestations, imaging and general examination, pathological features, treatment plan and clinical follow-up results were summarized. Main Outcome Measures Clinical and pathological characteristics, treatment and follow-up results. Results Of the all 7 patients, 5 were unifocal lesions and 2 were multifocal lesions. All patients were male with an age range of 8 months to 10 years. Course range was 3 days to 2 months. The clinical manifestations of unifocal lesions were monocular, with eyelid swelling as the main symptom, 1 case with eyelid mass. The clinical manifestations of multifocal lesions were monocular or binocular eyes, with exophthalmos as the main symptom, and 1 case with red eyes and tears. On CT images in unifocal lesions, there were lateral and upper orbital soft tissue mass with typical wormlike destruction of peripheral cranio-orbital bone. In multifocal lesions, there was monocular or bilateral orbital soft tissue mass with multiple map bone defect of cranio-orbital bone, and 1 case with insect-like destruction of rib. There were iso-hypointense on T1-weighted MR imaging and iso-hyperintense mixed signals on T2-weighted imaging. With T1 enhancement, most of the cases lesions presented obvious marked enhancement at the edges and the surrounding tissues, and with heterogeneous obvious enhancement of the lesion center. On histopathology, there were clonal proliferation of pathological Langerhans cells with infiltration of monocytes, lymphocytes and eosinophils. On immunohistochemical staining, CD1a, CD207 and S100 were showed positive signals. In unifocal lesions, all the 5 cases were treated with complete resection, curettage of bone cavity and repair of bone defect, combined with intraoperative or postoperative local triamcinolone acetonide injection. In multifocal lesions, one patient with monocular involvement underwent complete resection, curettage of bone cavity and local triamcinolone acetonide injection, and the other patients with binocular involvement underwent surgical biopsy. Multifocal lesion patients were also treated with systemic intravenous chemotherapy after operation. In unifocal lesions, the lesions disappeared completely without recurrence and were followed up for 30-85 months. In multifocal lesions for the observation 12-13 months, the disease was stable during treatment. Conclusions Children orbital LCH has typical clinical manifestations of eyelid swelling or exophthalmos. CT or MRI imaging and pathological examination are the basis of diagnosis. Complete resection of the focus, curettage of the bone cavity and local corticosteroid injection should be selected for unifocal lesions. Patients with multifocal lesions should be examined to exclude other systemic diseases, and intravenous chemotherapy after surgical resection is needed. (Ophthalmol CHN, 2021, 30: 300-306)





The clinical data and problems analysis of prehospital diagnosis and treatment in 51 cases with sebaceous gland carcinoma

Huang Zhengtai, Zhang Ke, Wang Lili, Zhu Yu

2021, 30(4):  307-311.  doi:10.13281/j.cnki.issn.1004-4469.2021.04.011

Asbtract ( 373 )  

Related Articles | Metrics

Objective To analyze the clinical data and the existing problems of prehospital diagnosis and treatment in sebaceous gland carcinoma (SGC). Design Retrospective case series. Participants 51 cases of SGC in the First Affiliated Hospital of Zhengzhou University. Methods The clinical data and the existing problems of prehospital diagnosis and treatment of patients with SGC were analyzed. Main Outcome Measures Clinical data, onset age of disease, prehospital diagnosis and treatment course, posthospital condition and TNM stage. Results The average age of 51 patients with SGC was 59.8±13.0 years. 29 cases were on upper eyelid and 22 cases on lower eyelid. The medical history was 6 months and less in 15 cases (29.4%) and more than 6 months in 36 cases (70.6%). Prehospital diagnosis included 39 cases of eyelid tumor, 6 cases of palpebral conjunctivitis and 6 cases of chalazion. 40 patients underwent at least one and up to five operations during prehospital treatment. Among the 31 cases, 14 cases of SGC, 15 cases of other eyelid tumors, 1 case of sebaceous hyperplasia and 1 case of chalazion. On admission, 29 cases had recurrent eyelid tumors, 15 cases were referred to further treatment duo to maligmant transformation, and 7 cases did not receive treatment. On admission, 3 cases were at TNM T1 stage, 29 cases at TNM T2 stage, 13 cases at TNM T3 stage and 6 cases at TNM T4 stage. Conclusion About 70% of the patients with SGC in this group did not receive appropriate treatment within 6 months of onset. The misdiagnosis rate of clinical and pathogical diagnosis was high. The treatment was not standard, and most of the patients were recurrent and advanced cases at admission. At present, the diagnosis and treatment of patients with SGC in primary and second hospitals remain to be standardized. (Ophthalmol CHN, 2021, 30: 307-311)





The efficacy of foldable capsular vitreous body implantation in the treatment of severe traumatic ruptures and silicone oil dependent eyes

Wang Dayu, Zhu Xiaobo, , Yang Yan, Li Yan, Zhang Wei, Li Jing

2021, 30(4):  311-315.  doi:10.13281/j.cnki.issn.1004-4469.2021.04.012

Asbtract ( 629 )  

Related Articles | Metrics

 Objective To investigate the efficacy of foldable capsular vitreous body (FCVB) primary implantation in severe traumatic ruptures with loss of intraocular tissue and secondary implantation in silicone oil dependent eyes. Design Retrospective case series. Participants From 2017 to 2020, patients with eye traumatic ruptures (7 cases) and silicone oil dependent eyes (14 cases) underwent FCVB implantation in Beijing Aier-Intech Eye Hospital. Methods The medical records of 21 FCVB implantation patients were reviewed. The average follow-up period was (15.6±9.8) months. Main Outcome Measures Visual acuity, intraocular pressure（IOP）, anterior chamber depth, retinal reattachment and appearance. Results In 21 patients 17 cases were male (81.0%). The average age was (36.1 ± 14.2) years old. There were no serious complications during surgery in all cases. Visual acuity was improved in 8/21 cases after FCVB surgery. The mean IOP was (6.81±3.34) mmHg before surgery and (11.62±5.44) mmHg at the last follow-up. All patients had anterior chamber depth 2.5 CT or more. The retina of all patients was reattached and satisfactory appearance was obtained. No obvious emulsification or leakage of silicone oil was observed. Conclusion The primary FCVB implantation in traumatic ruptures with loss of intraocular content eyes and the secondary FCVB implantation in silicone oil dependent eyes, can maintain eyeball shape and intraocular pressure in a certain period of time, reduce the burden of multioperation injuries. (Ophthalmol CHN, 2021, 30: 311-315)