Abstract: Objective To analyze the clinical data and the existing problems of prehospital diagnosis and treatment in sebaceous gland carcinoma (SGC). Design Retrospective case series. Participants 51 cases of SGC in the First Affiliated Hospital of Zhengzhou University. Methods The clinical data and the existing problems of prehospital diagnosis and treatment of patients with SGC were analyzed. Main Outcome Measures Clinical data, onset age of disease, prehospital diagnosis and treatment course, posthospital condition and TNM stage. Results The average age of 51 patients with SGC was 59.8±13.0 years. 29 cases were on upper eyelid and 22 cases on lower eyelid. The medical history was 6 months and less in 15 cases (29.4%) and more than 6 months in 36 cases (70.6%). Prehospital diagnosis included 39 cases of eyelid tumor, 6 cases of palpebral conjunctivitis and 6 cases of chalazion. 40 patients underwent at least one and up to five operations during prehospital treatment. Among the 31 cases, 14 cases of SGC, 15 cases of other eyelid tumors, 1 case of sebaceous hyperplasia and 1 case of chalazion. On admission, 29 cases had recurrent eyelid tumors, 15 cases were referred to further treatment duo to maligmant transformation, and 7 cases did not receive treatment. On admission, 3 cases were at TNM T1 stage, 29 cases at TNM T2 stage, 13 cases at TNM T3 stage and 6 cases at TNM T4 stage. Conclusion About 70% of the patients with SGC in this group did not receive appropriate treatment within 6 months of onset. The misdiagnosis rate of clinical and pathogical diagnosis was high. The treatment was not standard, and most of the patients were recurrent and advanced cases at admission. At present, the diagnosis and treatment of patients with SGC in primary and second hospitals remain to be standardized. (Ophthalmol CHN, 2021, 30: 307-311)

Key words: sebaceous gland carcinoma, misdiagnosis and mistreatment