Abstract:  Objective To observe the progress of myopia in children with myopia after wearing frame glasses with 0.05 D and 0.25 D spherical lens interval. Design Retrospective case series. Participants 126 consecutive myopia children wore spectacles with 0.05 D spherical interval (53 cases, 25 males) and 0.25 D spherical interval (73 cases, 38 males) design from 2019 to 2021 in Beijing Tongren Hospital. Methods The data of 126 children in electronic medical record system of Beijing Institute of Ophthalmology was retrospectively analyzed. Extract relevant information including age, gender, diopter, time between before and after optometry, lens type, etc. The method and environment of optometry, material, manufacturing process and manufacturer of the two sets of lenses were the same, and the only difference was that the adjustment interval of the spherical lens when obtaining the prescription was 0.05 D and 0.25 D respectively. The data of the right eye was taken into the statistical analysis. The progression of myopia in the two groups was compared using independent sample t test and generalized estimating equation. Main Outcome Measures The monthly average changes of spherical equivalents. Results In 0.05 D spherical interval group and 0.25 D spherical interval group, the mean ages was 8.2±2.3 and 8.7±2.4 years, respectively (t=-1.276, P=0.204). The interval time between two adjacent prescriptions was 9.5±5.6 and 11.2±5.6 months respectively (t=-1.692, P=0.093). The equivalent spherical lenses was -2.24±1.49 D and -2.46±2.42 D respectively at the first prescription (t=0.587, P=0.558). The equivalent spherical lenses was -2.76±1.65 D and -3.36±2.62 D respectively in the second prescription (t=1.457, P=0.148). The equivalent spherical lens changes between the two prescriptions was -0.52±0.60 D and -0.89±0.79 D respectively (t=2.887, P=0.005). The monthly average changes of spherical equivalents was -0.05±0.05 D and -0.09±0.05 D, respectively (t=4.582, P<0.001). Through generalized estimating equation analysis, the average monthly equivalent spherical lens change was not correlated with age (χ2=11.241, P=0.260), but was correlated with the interval between prescription spherical lenses (χ2=32.826, P<0.001) and the time interval between two prescriptions (χ2=198.715, P<0.001). Conclusion Compared with adjusting the spherical lens at 0.25 D interval, the frame glasses made by adjusting the spherical lens at 0.05 D interval shows a tendency to delay the progression of children's myopia, which is worth verifying by further randomized controlled experiments. （Ophthalmol CHN, 2022, 31: 89-93）

Key words:  spherical lens, interval, myopia control