Ophthalmology in China ›› 2022, Vol. 31 ›› Issue (3): 219-224.doi: 10.13281/j.cnki.issn.1004-4469.2022.03.010

Previous Articles     Next Articles

Biomechanical changes of isolated porcine anterior capsular membrane after chemical processing with sodium hypochlorite

Pei Yajing1, Han Shaofeng2, Lu Mingfeng1, Yang Yang3, Ma Ke1   

  1. 1 Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China； 2 School of Energy Power and Mechanical Engineering, North China Electric Power University, Beijing 102206, China; 3 School of Mechanical Engineering and Automation, Beihang University, Beijing 100191, China
  • Received:2022-03-12 Online:2022-05-25 Published:2022-06-07
  • Contact: Ma Ke, Email: cdmake@163.com E-mail:cdmake@163.com
  • Supported by:
    National Key Research & Development Project (2017YFB1302705)

Abstract: Objective To study the changes of biomechanical parameters of isolated porcine anterior capsular membrane after chemical treatment with sodium hypochlorite. Design Experimental study. Participants 48 porcine eyeballs and 8 cadaveric eye lenes. Methods Porcine eyeballs were randomly divided into four groups (12 eyes each group): group A (untreated group), group B, C and D (treated with 0.1%, 0.3% and 0.5% sodium hypochlorite respectively in the anterior capsule). Eight cadaveric eyes lens were marked as group E. In B, C and D group, the anterior capsular surface was placed horizontally upward. No special treatment was performed in group A. In groups B, C and D, 0.1%, 0.3% and 0.5% sodium hypochlorite were dripped on the surface of anterior capsule for 5 minutes. Cataract expert used micro-force-sensing capsulorhexis forceps to perform continuous circular capsulorhexis on five groups of lenses, evaluated the feel of capsulorhexis by the questionnaire and recorded the biomechanical data of capsulorhexis in real time by the interrogator. Main Outcome Measures Score of the evaluation questionnaire on the hand feeling of capsulorhexis; biomechanical indexes include maximum capsulorhexis force and average capsulorhexis force. Results According to the doctor's score on the feel of piercing and tearing the lens of porcine, the average score of group A was 4±0, and the average score of groups B, C and D was 3±0 respectively. The maximum tear force in group A to E was 34.53±6.02 mN, 29.49±7.00 mN, 28.94±4.71 mN, 26.14±2.39 mN, 24.06±8.18 mN, respectively (H=15.07, P=0.005). The average tear force was 15.58±3.04 mN, 13.48±4.05 mN, 12.67±2.59 mN, 11.40±1.65 mN, 10.98±4.33 mN, respectively (H=13.79, P=0.008). There were significant differences between group A and D, in the maximum (Z=19.33, P=0.037) and average tear force (Z=20.33, P=0.023); there were significant differences between group A and E in the maximum (Z=26.58, P=0.004) and average tear force (Z=24.04, P=0.012), but there were no significant differences between the other groups. Conclusion The capsulorhexis force of fresh porcine anterior capsule treated with 0.5% sodium hypochlorite is most close to that of human anterior capsule, and the treated porcine anterior capsule can be used for the capsulorhexis training of surgery beginners and robots. (Ophthalmol CHN, 2022, 31: 219-224)

Key words: anterior lens capsule, continuous circular capsulorhexis, animal model