Table of Content

25 May 2022, Volume 31 Issue 3

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The value of laser retinal photocoagulation in clinical management of retinal vein occlusion in era of anti-VEGF

Li Yibin

2022, 31(3):  165-168.  doi:10.13281/j.cnki.issn.1004-4469.2022.03.001

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Retinal vein occlusion (RVO) is the most common retinal vascular disease second to diabetes retinopathy. The main causes of its visual impairment are macular edema (ME) and ocular neovascularition (NV), especially neovascular glaucoma (NVG). Although the efficacy of laser retinal photocoagulation has long been determined for treatment of ME, NV and NVG, anti-vascular endothelial growth factor (VEGF) therapy can effectively improve the visual outcomes of RVO patients, and has become the first-line treatment for ME and helpful for the treatment of NV and NVG. Recent studies have shown that addition of laser cannot lead to better visual acuity or lower the number of injections in anti-VEGF treatment for RVO-ME, while intravitreal anti-VEGF therapy delayed, but could not prevent NV complication. Scatter laser photocoagulation plays a pivotal role in treatment of NV complications, but prophylactic laser treatment should not be encouraged. (Ophthalmol CHN, 2022, 31: 165-168)

Angle-closure glaucoma and lens suspensory ligament：re-evaluation

Tang Li, Wang Ningli, Fan Ning, Liu Xuyang

2022, 31(3):  169-174.  doi:10.13281/j.cnki.issn.1004-4469.2022.03.002

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The position of the lens plays an important role in the pathogenesis of primary angle-closure disease (PACD). Abnormal of zonular fibers and subsequent lens dislocation can affecting lens size and shape, cause the anterior chamber to become shallow or unstable. Factors such as aging, genetics, trauma and inflammation may affect the structure and function of the zonule and lead to angle-closure glaucoma. Studying the zonule in PACD helps us understand some clinical phenomena such as why myopia is not uncommon in patients with angle-closure; sometimes, the anterior chamber may become shallower and in turn, the aqueous misdirection or malignant glaucoma may occur after using pilocarpine for PACD; younger PACD may often have systemic genetic disease, etc. But at present there is no simple and accurate methods to assess the zonule at preoperation or intraoperation. (Ophthalmol CHN, 2022, 31: 169-174)

Modified trabeculectomy combined with deep sclerectomy

Gao Yan, Xin Chen, Shi Yan, Yu Xiaowei, Fan Zhigang

2022, 31(3):  175-180.  doi:10.13281/j.cnki.issn.1004-4469.2022.03.003

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Trabeculectomy has always been the most classic anti-glaucoma surgery, and it is also the representative of external filtration surgery with the widest indications and the largest reduction of intraocular pressure (IOP). According to its mechanism of IOP control and history for improvement, the authors summarize and put forward a more optimized modification-modified trabeculectomy combined with deep sclerectomy. This modified surgery reduces IOP with large amplitude through a variety of mechanisms, and can effectively avoid the long-term complications related to filtering bleb at the same time. The surgical indications are the same as trabeculectomy, and is more suitable for patients with advanced glaucoma. The surgical procedures are easy to learn and postoperative complications are relatively rare. (Ophthalmol CHN, 2022, 31: 175-180)

Efficacy and effective factors of vitrectomy for vitreous hemorrhage secondary to polypoidal choroidal vasculopathy

Zhou Haiying, Ji Haixia, Yang Xuan, Ma Kai

2022, 31(3):  181-187.  doi:10.13281/j.cnki.issn.1004-4469.2022.03.004

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Objective To describe the outcomes and related effective factors of pas plana vitrectomy (PPV) for vitreous hemorrhage (VH) secondary to polypoidal choroidal vasculopathy (PCV). Design Retrospective case series. Participants 294 eyes of 294 cases with VH secondary to PCV that underwent PPV from 2012 to 2020 in Beijing Tongren Hospital. Methods Medical records of all 294 patients were reviewed, including demographics and clinical characteristics of patients，different intraocular tamponades and visual acuity prognosis. The related factors of visual acuity prognosis including demographics and clinical characteristics of patients, systemic dieaseses, application of anti-vascular endothelial growth factor (VEGF) and surgery related data were also analyzed. Logisic analysis was used for studying related factors of visual acuity prognosis. The median of follow-up period was 120 days (range 90~750 days). Main Outcome Measures LogMAR best corrected visual acuity（BCVA）, application of anti-VEGF or not, duration of surgery, incidence of intraoperative retinal hole, proportion of retinotomy, different intraocular tamponades. Results The mean logMAR BCVA before PPV (2.22±0.47, 0.3~2.9) had improved significantly at the last visit after the operations (1.66±0.64, 0.1~1.85) (P<0.0001). Diabetes might be associated with poor postoperative BCVA (P=0.0375). In the patients without anti-VEGF treatment before PPV, the incidence of intraoperative retinal hole and the proportion of inert gas or silicon oil tamponade were higher (P=0.015). Compare with patients with BSS or air tamponade, patients with inert gas or silicon oil tamponade had lower proportion of anti-VEGF treatment (27.50% VS 48.03%, P=0.0150) , lower rate of posterior vitreous detachment (PVD) preoperatively (27.50% VS 53.94%, P=0.043), but had higher incidence of intraoperative retinal hole (50.00% VS 1.97%) , higher proportion of retinotomy (30.00% VS 0.00%) during surgery (all P<0.001), longer surgery duration (102.33±58.78 VS 50.7±22.16, P<0.0001), and poorer postoperative logMAR BCVA （1.86±0.62 VS 1.63±0.64，P=0.0352）. Conclusion PPV is effective for VH patients secondary to PCV, which can improve/stabilize visual function. Preoperative anti-VEGF treatment may play a significant role in reducing intraoperative complications, reducing the proportion of silicon oil tamponade, and improving the visual prognosis. (Ophthalmol CHN, 2022, 31: 181-187)

Accuracy of Haigis and SRK/T formulas in calculating intraocular lens power for vitrectomy combined with phacoemulsification in pathological myopia

Huang Yao, Li Qian, Chen Yanyun, Xiang Fei, Tian Bei

2022, 31(3):  190-194.  doi:10.13281/j.cnki.issn.1004-4469.2022.03.005

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Objective To compare the calculation accuracy of Haigis and SRK/T formulas in patients with pathological myopia who underwent vitrectomy combined with cataract phacoemulsification and IOL implantation. Design Retrospective case series. Participants Twenty-six patients (40 eyes) with pathological myopia who underwent vitrectomy combined with cataract phacoemulsification and IOL implantation in Beijing Tongren Eye Center. Methods The medical records of patients were reviewed. All patients underwent IOL Master 500 examination before the surgeries. Three months postoperatively, the patients underwent optometry. Postoperative spherical equivalent was calculated. The prediction error (PE) and absolute prediction error (APE) of Haigis and SRK/T formulas were calculated. PE means actual postoperative spherical equivalent subtract postoperative diopter predicted by IOL formula. The absolute value of PE is APE. According to the axial length (AL), the study eyes were divided into three groups: AL< 28 mm, 28~30 mm and AL>30 mm. Differences between the indicators of the two formulas in the three groups were analyzed. Main Outcome Measures PE, APE. Results The mean PE values of the two IOL calculation formulas were both positive, suggesting that the calculation results drift towards hyperopia. The PE value of Haigis formula is (0.63±0.93) D and that of SRK/T formula was (0.61±1.17) D with no significant difference. The APE value of Haigis formula was (0.85±0.74) D, and that of SRK/T formula was (0.97±0.89) D with no significant difference. In 26 eyes with axial length ≤30 mm, there was no significant difference in PE or APE value between Haigis and SRK/T formula. In 14 eyes with axial length >30 mm, there was no significant difference on PE values between Haigis and SRK/T formula (t=-0.819, P=0.420). The APE value of Haigis formula was (0.84±0.49) D and that of SRK/T formula was (1.33±1.07) D with a significant difference (t=-2.619, P=0.015). Conclusion Haigis formula was more accurate than SRK/T formula when the axial length was >30 mm in patients with pathological myopia undergoing vitrectomy combined with cataract phacoemulsification and IOL implantation. When the axial length was ≤30 mm, there was no significant difference in the accuracy of Haigis and SRK/T formulas in calculating IOL power. Postoperative diopter shift to hyperopia. (Ophthalmol CHN, 2022, 31: 190-194)

Changes of retinal vascular caliber in early stages of diabetic retinopathy in type 2 diabetes

Shen Zhijun, She Chongyang, Li Yunyun, Liu Ningpu

2022, 31(3):  195-199.  doi:10.13281/j.cnki.issn.1004-4469.2022.03.006

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Objective To assess the changes and associations of retinal vascular caliber in early stages of diabetic retinopathy (DR) in type 2 diabetic patients. Design Case-control study. Participants 85 patients with type 2 diabetes (51~80 years old) and 26 age-sex-matched subjects without diabetes (51~78 years old) from Beijing Desheng Community Diabetic Eye Disease Study were used as controls. Methods 85 patients with type 2 diabetes were divided into two groups according to DR: no DR (NDR) group (51 cases), and mild to moderate nonproliferative diabetic retinopathy (NPDR) group (34 cases), compared with 26 non-diabetic control subjects. Central retinal arterial equivalence (CRAE) and central retinal vein equivalence (CRVE) were measured using computer software. Central macular retinal thickness was measured using spectral domain optical coherence tomography (OCT). Best corrected visual acuity (BCVA), diabetes duration, height, weight, glycosylated hemoglobin and other data were recorded. The differences of CRAE and CRVE among the three groups were compared, and possible related factors were analyzed. Main Outcome Measures CRAE, CRVE. Results The CRAE of the right eye of the non-diabetic control group, the right eye of the NDR group and the severely diseased eye of the NPDR group were (151.91±13.65) μm, (156.73±11.53) μm, (154.08±9.82) μm (F=1.58, P=0.21); CRVE was (226.60±11.84) μm, (231.70±15.65) μm, (244.59±13.82) μm (F=13.43, P<0.01); CRVE in NPDR group was significantly wider than that in non-diabetic control group and NDR group (P<0.01 for both), while there was no statistical difference of CRVE between the control and NDR groups (P=0.42). Multivariate linear regression analysis showed that CRVE was negatively correlated with age in the three groups (P<0.01, all). Conclusion CRVE in the three groups of patients in this study was negatively correlated with age; CRVE in NPDR group was significantly wider compared with the control and NDR group. (Ophthalmol CHN, 2022, 31: 195-199)

SD-OCT findings of retina outer layers in acute central serous chorioretinopathy

Zhang Cong, Shi Xuehui, Yao Ning, Diao Lili, Wei Chuanchuan

2022, 31(3):  200-204.  doi:10.13281/j.cnki.issn.1004-4469.2022.03.007

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Objective To investigate the features of the retina outer layers on images of spectral domain optical coherence tomography (SD-OCT) in acute central serous chorioretinopathy (CSC). Design Retrospective case series. Participants 55 eyes of 55 patients who were diagnosed as unilateral and initial onset of acute CSC with one obvious leakage point (LP) on fundus fluorescence angiography (FFA) images. Methods The morphology of RPE reflective layer at LP, macular fovea (MF) and neurosensory retinal detachment (NSRD) were investigated, and the morphology features of NSRD were also analyzed on SD-OCT with Spectralis HRA+OCT. Main Outcome Measures The subtypes of PED, the morphologic and structural changes of the retina outer layers on the SD-OCT. Results 41 eyes(74.5%) of LP displayed as PED, among which 15 eyes (27.3%) presented as dome-shaped PED (DSPED) and 26 eyes (47.2%) flat irregular PED (FIPED) . FIPED was prone to display as inkblot leakage (χ2=11.116，P=0.001) and locate outside of foveal avascular zone (FAZ) (χ2=4.432，P=0.035) compored with DSPED. 6 eyes (10.9%) in MF and 9 eyes (16.4%) in NSRD presented as FIPED. 55 eyes (100%) manifested thickening hyper-reflectivity of outer plexiform layer (OPL) and 53 eyes (96.4%) demonstrated with fusiform or multiple irregular hypo-reflective regions within OPL, which seemed as splitting of OPL. The external limiting membrane (ELM) of 55 eyes (100%) was intact and distinct. The outer segments of photoreceptors layer (PRL-OS) of 44 eyes (80.0%) were thickening and with vague ellipsoid zone (EZ) and interdigitation zone (IZ). The boundary of PRL-OS in 44 eyes (80.0%) showed granular appearance and in 41 eyes (74.5%) accompanied with hyperreflective dots (HRD). Conclusion FIPED in acute CSC is not rare, and the thickening of PRL-OS, granular appearance of PRL-OS and indistinction of EZ and IZ are frequently-occurring signs. The appearance of splitting-shaped hypo-reflecitive regions within thickening OPL of NSRD is a common and important sign in acute CSC. (Ophthalmol CHN, 2022, 31: 200-204)

Efficacy of scleral fixated intraocular lens implantation with knotless Z-suture technique for inadequate capsule/zonular support

Qi Meng, He Lei

2022, 31(3):  207-212.  doi:10.13281/j.cnki.issn.1004-4469.2022.03.008

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Objective To observe the efficacy of the scleral fixated intraocular lens implantation with knotless Z-suture technique for moderate severe inadequate capsule/zonular support. Design Retrospective case series. Participants Eighty-eight eyes of 78 Moderate to severe inadequate capsule/zonular support patients, who were cases with over 180°zonular weakness or residual capsule inadequate to support intraocular lens ciliary groove implantation, were included from July 2017 to January 2021 in Ocular Trauma Department of Beijing Tongren Hospital. Methods All patients underwent surgeries including the standard procedure of scleral fixated intraocular lens implantation with knotless Z-suture technique. The median follow-up duration was 19 months (range 12~50, quartile 15~25.5 months). Preoperative and postoperative visual acuity, complications, intraocular lens position were observed. Main Outcome Measures Uncorrected visual acuity, best corrected visual acuity (BCVA), complications, and intraocular lens position. Results The uncorrected visual acuity was hand motions～0.4 at baseline. It improved to 0.04～1.0 at 6th month follow-up including 80 eyes (90.9%)≥0.3. The BCVA improved significantly from 0.79±0.36 at baseline to 0.20±0.15 at last follow-up (t=-9.783, P<0.001). No suture-related complications such as wound leakage at the sutures, sclera thinning, sclera melting, chronic inflammation around the suture, suture erosion, suture exposure, and endophthalmitis was observed in any cases. The Z-sutures were invisible in all cases under the slit lamp microscopy. Complications requiring invasive treatment were retinal detachment in 1 eye (1.1%) and intraocular lens pupillary capture in 1 eye (1.1%). Both cases were children with Marfan syndrome. All the other intraocular lens were in the expected position without obvious pseudophakodonesis, dislocation, decentration or tilt. No cystoid macular edema, corneal endothelial decompensation, secondary glaucoma, suprachoroidal hemorrhage or endophthalmitis was observed. Conclusion Knotless Z-suture technique can effectively reduce the occurrence of suture-related complications which is applicable for various cases of moderate to severe inadequate capsule/zonular support. (Ophthalmol CHN, 2022, 31: 207-212)

Correction efficacy of Toric implantable collamer lens implantation for high ocular residual astigmatism

Xiong Ying, Yao Qinnan, Wan Xiuhua

2022, 31(3):  213-218.  doi:10.13281/j.cnki.issn.1004-4469.2022.03.009

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Objective To compare the correction efficacy of Toric implantable collamer lens (TICL) implantation for high ocular residual astigmatism (HORA) with that for low ocular residual astigmatism (LORA). Design Retrospective case series. Participants A total of 200 eyes of 100 patients underwent TICL implantation from July to December 2020 at Beijing Tongren Eye Center. Methods Total astigmatism was obtained by subjective refraction using corneal topography (iTrace visual function analyzer) before surgery. The difference between total astigmatism and corneal astigmatism was calculated by the vector analysis method to obtain intraocular astigmatism (ocular residual astigmatism, ORA). According to the magnitude of ORA, the surgical eyes were divided into HORA group (ORA≥1.30 D, 94 eyes) and LORA group (ORA<1.30 D, 106 eyes). Then, the standard vector analysis method recommended by the American National Standards Institute (ANSI) was used to calculate the intended refractive correction (IRC) and surgically induced refractive correction (SIRC) in both groups. The ratio of SIRC to IRC is the correction ratio (CR). CR equal to 1 represents the most ideal correction, CR>1 indicates overcorrection of astigmatism, and CR<1 indicates undercorrection of astigmatism. The difference between SIRC and IRC is the error vector (EV), and the ratio between EV and IRC is the error rate (ER). When ER is 0, it represents the most ideal correction, and when ER is 1, it represents no correction at all. The differences of the above parameters between the two groups were compared. Main Outcome Measures IRC, SIRC, CR, EV, ER. Results In the HORA group, the IRC, SIRC, CR, EV, ER was 1.52 (0.88~2.60)D, 1.47 (0.83~2.53)D, 0.91 (0.75~1.16), 0.67 (0.39~1.04)D and 0.43 (0.24~0.90) respectively at 1 week after operation; was 1.52 (0.88~2.60)D, 1.37 (0.68~2.43)D, 0.92 (0.69~1.15) , 0.7 (0.43~1.14)D and 0.49 (0.28~1.02) respectively at 6 months after surgery. In the LORA group, the IRC, SIRC, CR, EV, ER was 1.18 (0.53~1.70)D, 1.1 (0.59~1.91)D, 1.03 (0.66~1.49), 0.57 (0.29~1.00)D and 0.62 (0.31~1.02) respectively at 1 week after operation; was 1.12(0.53~1.68)D, 0.93(0.50~1.67)D, 0.91(0.61~1.24), 0.54(0.28~1.07)D and 0.61(0.32~1.13) respectively at 6 months after surgery. Comparing the HORA group with the LORA group, there were significant differences in IRC and SIKC (P<0.01, 0.01), but no significant difference in CR, EV and ER at 1 week after operation. There were significant differences in IRC, SIRC and EV at 6 months after operation(P<0.01, <0.01, 0.03), but no significant difference in CR and ER. Conclusion Toric Implantable collamer lens (TICL) have the same good correction effect for astigmatism in the HORA group as in the LORA group. (Ophthalmol CHN, 2022, 31: 213-218)

Biomechanical changes of isolated porcine anterior capsular membrane after chemical processing with sodium hypochlorite

Pei Yajing, Han Shaofeng, Lu Mingfeng, Yang Yang, Ma Ke

2022, 31(3):  219-224.  doi:10.13281/j.cnki.issn.1004-4469.2022.03.010

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Objective To study the changes of biomechanical parameters of isolated porcine anterior capsular membrane after chemical treatment with sodium hypochlorite. Design Experimental study. Participants 48 porcine eyeballs and 8 cadaveric eye lenes. Methods Porcine eyeballs were randomly divided into four groups (12 eyes each group): group A (untreated group), group B, C and D (treated with 0.1%, 0.3% and 0.5% sodium hypochlorite respectively in the anterior capsule). Eight cadaveric eyes lens were marked as group E. In B, C and D group, the anterior capsular surface was placed horizontally upward. No special treatment was performed in group A. In groups B, C and D, 0.1%, 0.3% and 0.5% sodium hypochlorite were dripped on the surface of anterior capsule for 5 minutes. Cataract expert used micro-force-sensing capsulorhexis forceps to perform continuous circular capsulorhexis on five groups of lenses, evaluated the feel of capsulorhexis by the questionnaire and recorded the biomechanical data of capsulorhexis in real time by the interrogator. Main Outcome Measures Score of the evaluation questionnaire on the hand feeling of capsulorhexis; biomechanical indexes include maximum capsulorhexis force and average capsulorhexis force. Results According to the doctor's score on the feel of piercing and tearing the lens of porcine, the average score of group A was 4±0, and the average score of groups B, C and D was 3±0 respectively. The maximum tear force in group A to E was 34.53±6.02 mN, 29.49±7.00 mN, 28.94±4.71 mN, 26.14±2.39 mN, 24.06±8.18 mN, respectively (H=15.07, P=0.005). The average tear force was 15.58±3.04 mN, 13.48±4.05 mN, 12.67±2.59 mN, 11.40±1.65 mN, 10.98±4.33 mN, respectively (H=13.79, P=0.008). There were significant differences between group A and D, in the maximum (Z=19.33, P=0.037) and average tear force (Z=20.33, P=0.023); there were significant differences between group A and E in the maximum (Z=26.58, P=0.004) and average tear force (Z=24.04, P=0.012), but there were no significant differences between the other groups. Conclusion The capsulorhexis force of fresh porcine anterior capsule treated with 0.5% sodium hypochlorite is most close to that of human anterior capsule, and the treated porcine anterior capsule can be used for the capsulorhexis training of surgery beginners and robots. (Ophthalmol CHN, 2022, 31: 219-224)

Prevention efficacy of desktop virtual reality display on digital eye strain

Zhen Yi, Gao Jie, Zhang Wei, Cheng Dewen, Shen Wenrui, Wang Ningli

2022, 31(3):  225-230.  doi:10.13281/j.cnki.issn.1004-4469.2022.03.011

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Objective To investigate the preventive effect of desktop virtual monitors on digital eye fatigue caused by watching videos at close range. Design Crossover design experiment study. Participants 31 adult healthy subjects. Methods The subjects were randomly divided into two groups. The first group watched the same video for 10 minutes using a mobile phone and then a desktop virtual monitor, with a 30-minute break; the second group watched the same videos in reverse order. An open refractometer was used to record the diopter before, during and after watching the video, and the accommodative micro-fluctuation and accommodative error were calcuated. The data of the right eyes were used to analyse. The subjective visual fatigue score before and after watching the video was recorded using the Likert scale. Main Outcome Measures Diopter, accommodative micro-fluctuation, accommodative error and visual fatigue scale scores before and after watching videos. Results The diopter of the eyes using the mobile phone and using the desktop virtual monitor before watching the video was (-0.30±0.54) D and (-0.29±0.58) D, respectively (P=0.928). When watching the video for 5 minutes, the diopter of the eyes using mobile phone was (-3.32±0.68) D, which was significantly lower than that before watching the video (P=0.000); the diopter of the eyes using the desktop virtual monitor was(-0.39±0.63) D , which was not significantly different from that before watching the video(P=0.168); the accommodative micro-fluctuation of the mobile phone viewer and the desktop virtual monitor viewer was (0.33±0.10) D and (0.21±0.10) D, respectively (P=0.000); the accommodative error of the mobile phone viewer was lagging (0.25±0.68) D, and of the viewer using the desktop virtual monitor was leading (0.09±0.63) D (P=0.044). After watching the video, the diopter of the eyes using the mobile phone was (-0.53±0.56) D, which was significantly lower than that before viewing (P=0.000); the diopter of the eyes using the desktop virtual monitor was (0.34±0.61) D, which was no significant different compared with that before viewing (P=0.335). After watching the video, the visual fatigue scale score of the mobile phone viewers and the desktop virtual display viewers was increased (8.4±8.3) and (2.5±3.8), respectively (P=0.001). Conclusion Applying a desktop virtual display can prevent digital eye strain caused by watching videos at close range, which may be related to the lack of myopia adjustment during viewing. (Ophthalmol CHN, 2022, 31: 225-230)

Effect of calf blood deproteinized extract eye drops on improvement of ocular surface in adolescents wearing orthokeratology lenses

Wang Xiangjuan, Ying Wenchuang, Chen Shicheng, Song Jiali

2022, 31(3):  231-234.  doi:10.13281/j.cnki.issn.1004-4469.2022.03.012

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Objective To investigate the efficacy and safety of deproteinized calf blood deproteinized extract eye drops on ocular surface conditions in adolescent myopic patients wearing orthokeratology lenses. Design Case-control study. Participants A total of 116 adolescent myopic patients (232 eyes) wearing orthokeratology lenses admitted to Shaoxing Central Hospital from January 2018 to January 2021 were selected and randomly divided into the control group (58 cases, 116 eyes) and the observation group (58 cases, 116 eyes). Methods The control group wore orthokeratology lenses in routine and the observation group used calf blood deproteinized extract eye drops during the day on the basis (1 drop/eye, 4 times/day). The uncorrected visual acuity (UCVA), diopter and axial length, corneal curvature, corneal surface regularity index (SRI), tear break-up time (BUT), tear film lipid layer thickness (LLT), conjunctivitis, ocular hypertension, photophobia discomfort and the incidence of corneal epithelial staining complications were compared between the two groups after 1 month of treatment. Main Outcome Measures UCVA, diopter and axial length, corneal curvature, SRI, BUT, LLT, and complications. Results Compared with before treatment, the UCVA and diopter of the two groups were apparently improved after treatment, the corneal curvature was apparently reduced, and the SRI level was apparently increased (all P<0.05). There was no significant difference in UCVA, diopter, axial length, corneal curvature and SRI level between the two groups after the treatment (all P>0.05). Compared with before treatment, the levels of BUT and LLT in the two groups were apparently decreased after treatment (P<0.05), and the observation group [(7.34±2.10) s, (60.52±10.84) nm] was apparently higher than those in the control group [(6.26±2.03) s, (55.20±11.73) nm] (all P<0.001); after treatment, there was no significant difference in the incidences of conjunctivitis, high intraocular pressure and photophobia between the two groups (all P>0.05). The incidence of corneal epithelial staining (8.62%) was apparently lower than that of the control group (24.14%) (P=0.024). Conclusion The ocular surface condition can be improved after auxiliary instillation of calf blood deproteinized extract eye drops in adolescent myopic patients who wear orthokeratology lenses without affecting the correction effect of orthokeratology lenses. (Ophthalmol CHN, 2022, 31: 231-234)