Ophthalmology in China ›› 2023, Vol. 32 ›› Issue (2): 89-97.doi: 10.13281/j.cnki.issn.1004-4469.2023.02.003

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Extracellular matrix and associated congenital vitreous abnormalities

Huang Houbin   

  1. Department of Ophthalmology, Hainan Hospital of PLA General Hospital, Sanya 572013, China; Senior Department of Ophthalmology, PLA General Hospital, Beijing 100853, China; The Second School of Clinical Medicine, Southern Medical University, Guangzhou 510280, China
  • Received:2022-11-18 Online:2023-03-25 Published:2023-03-25
  • Contact: Huang Houbin, Email：536273642@qq.com
  • Supported by:
    Scientific Rresearch Project of Health Industry in Hainan Province (22A200351); Special Scientific Research Project of the Logistic Support Department of the Chinese Military Committee(19BJZ39); Health Care Special Project of PLA Logistics Research Fund (23BJZ37)

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Abstract: Vitreous is a kind of extracellular matrix in nature, consisting of collagen, hyaluronan, proteoglycan, etc. Mutations of the genes coding the protein components would result in various congenital vitreous abnormalities including membrane, beaded or hypoplastic phenotype. High myopia and retinal detachment are commonly associated. Comprehensively knowing the extracellular matrix components composing the vitreous is really helpful to understand deeply the congenital inherited vitreoretinopathies. (Ophthalmol CHN, 2023, 32: 89-97)

Key words: vitreous, extracellular matrix, Stickler syndrome, Knobloch syndrome, Wagner syndrome, Marfan syndrome