Ophthalmology in China ›› 2021, Vol. 30 ›› Issue (4): 290-294.doi: 10.13281/j.cnki.issn.1004-4469.2021.04.008

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Clinical characteristics of endogenous endophthalmitis in patients with acquired immunodeficiency syndrome

Liu Xiyao, Mao Feifei, Li Dan, Lu Dan, Wang Shengnan, Sun Huiyu   

  1. Department of Ophthalmology, National Clinical Key Department of Infectious Disease, Beijng Ditan Hospital, Capital Medical University, Beijing 100015, China

  • Received:2021-01-13 Online:2021-07-25 Published:2021-07-22
  • Contact: Sun Huiyu, Email: sunhuiyu123@126.com
  • Supported by:
    Beijing Hospitals Authority Incubating Program (PX2018061); Beijing Municipal Administration of Hospitals’ Ascent Plan (DFL20191802); Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (ZYLX202126)

Abstract: Objective To investigate the clinical characteristics of endogenous endophthalmitis in patients with acquired immunodeficiency syndrome. Design Retrospective case series. Participants 12 patients (15 eyes) with acquired immunodeficiency syndrome diagnosed with endogenous endophthalmitis in Beijing Ditan Hospital from 2014 to 2020. Methods The medical records of the patients were reviewed. Aqueous fluid tests include bacterial culture, fungal culture and detection of non-cultured suppurative pathogens or metagenomics next generation sequencing. Vitreous injection and/or vitrectomy were performed to treat. Main Outcome Measure Visual acuity, anterior segment and fundus manifestations, and aqueous humor test. Results All the 12 cases were male with an average age of 41.83±8.50 years. There were 4 cases of pulmonary tuberculosis, 5 cases of syphilis, 3 cases of cryptococcal meningitis, 3 cases (4 eyes) of cytomegalovirus retinitis, and 4 cases of fever. 6 eye had fungal endophthalmitis. 9 eye had bacterial endophthalmitis (staphylococcus aureus in 2 eyes, staphylococcus epidermidis in 1 eye, streptococcus in 1 eye, escherichia coli in 2 eyes, bradylosis streptococcus in 1 eye, haemophilus influenzae in 1 eye, sphingomonas paucimobilis in 1 eye). 7 eyes were complicated with virus infection (varicella zoster virus in 2 eyes, cytomegalovirus in 4 eyes, EB virus in 1 eye). Vitreous injections were performed in 14 eyes and vitrectomy was performed in 4 eyes. Endophthalmitis was controlled in 14 eyes, and 1 eye ruptured. Conclusion Early diagnosis and treatment of endogenous endophthalmitis with acquired immunodeficiency syndrome can control infection. The detection efficiency can be improved by bacterial culture and fungal culture in the intraocular fluid, combined with the detection technology of non-cultured pathogens. Attention should be paid to the presence of virus infection in these patinets. (Ophthalmol CHN, 2021, 30: 290-294)


Key words: acquired immunodeficiency syndrome, endogenous endophthalmitis, metagenomics next generation sequencing, vitreous injection, vitrectomy