Abstract: Objective To evaluate the short-term effects of intravitreal Conbercept injection (ICI) on intraocular pressure (IOP), retinal thickness, and choroidal thickness. Design Prospective cohort study. Participants A total of 42 patients with neovascular age-related macular degeneration treated with 0.05 ml intravitreal Conbercept injection (ICI) by the same physician between October 2020 and May 2021 were collected. Methods All subjects underwent general physical and ophthalmic examinations. Eye axial length (AL) was measured using IOL Master before ICI. To observe the changes of central subfoveal thickness (CFT), retinal nerve fibre layer (RNFL) thickness, subfoveal choroidal thickness (SFCT) and parafoveal choroidal thickness (PFCT) within 1 hour before ICI, 1 hour after ICI, and 24 hours after ICI. Factors associated with SFCT and PFCT measured within 1 hour before ICI were analyzed by multiple linear regression. Main Outcome Measures CFT, RNFL thickness, SFCT, PFCT. Results The IOP was 15.8±3.6 mmHg before the injection, 17.8±4.3 mmHg at 1 hour after the injection, and 13.8±2.6 mmHg at 24 hours after the injection, with a significant increase followed by a significant decrease after ICI (F=5.43, P=0.006). The PFCT was 244.2±78.8 μm before the injection, 197.3±84.1 μm at 1 hour after ICI, and 307.9±74.2 μm at 24 hours after ICI, with a significant decrease followed by a significant increase after ICI (F=3.48, P=0.04). There were no significant differences in CFT (F=0.19, P=0.83), RNFL (F=0.45, P=0.64) and SFCT (F=1.53, P=0.23) among the different time point before and after ICI. Both SFCT [B (95% CI): -7.77 (-12.25, -3.29), P=0.002] and PFCT [B (95% CI): -6.87 (-10.51, -3.23), P=0.005] were negatively associated with age. Conclusion ICI has an immediate effect on choroidal thickness in the short term, which may lead to transient choroidal ischemia that recovers 24 hours after ICI. (Ophthalmol CHN, 2023, 32: 478-482)

Key words:  intravitreal Conbercept injection, intraocular pressure, choroidal thickness