Abstract: Objective To investigate the short-term lowering intraocular pressure(IOP) effect between domestic latanoprost eye drops and Xalatan eye drops. Design A randomized, open, parallel control study. Participants Primary open angle glaucoma patients(POAG) and ocular hypertension(OHT) patients. Method Forty-two patients with POAG or OHT were randomly divided into two groups: Group A, 28 eyes of 28 patients, received domestic latanoprost eye drops. Group B, 14 eyes of 14 patients, received Xalatan eye drops. The IOP was measured at 8:00, 11:00, 14:00, 16:00 at the first day  the 28th day after the eye drops was given. The IOP was measured at 8:00 at the 7th, 14th and 21th day. The IOP was measured three times with Goldmann tonometer and an average value was obtained. Cornea, iris and lens were observed with slit lamp. Main Outcome Measures IOP. Results The baseline IOP in group A was 23.99±1.54 mmHg. The IOP was 18.04±1.27 mmHg, 17.75±1.43 mmHg, 17.63±1.50 mmHg, 17.49±1.47 mmHg after 1, 2, 3 and 4 weeks respectively. Significant difference was found between baseline IOP  and IOP at any time point after eye drops used (F=105.72, P=0.000). The baseline IOP in group B was 24.37±1.55 mmHg. The IOP was 17.91±1.35 mmHg, 17.71±1.39 mmHg, 17.55±1.34 mmHg, 17.44±1.17 mmHg after 1, 2, 3 and 4 weeks respectively. Significant difference was found between baseline IOP and IOP at any time point after eye drops used (F=67.85, P=0.000). No significant difference was found between baseline IOP in group A and in group B(P=0.43). No significant difference was found at any time point between group A and group B after 1, 2, 3 and 4 weeks(P= 0.76, 0.93, 0.86, 0.89 respectively). No significant difference was found between group A and group B in IOP at the time point 8:00, 11:00, 14:00, 16:00 before eye drops instilling（P= 0.46, 0.44, 0.50, 0.31）. And also no significant difference was found between group A and group B in IOP at the time point 8:00, 11:00, 14:00, 16:00 after eye drops instilling (P= 0.89, 0.85, 0.94, 0.98). No abnormality was found in cornea, iris and lens at 28 days after medication in both groups. Conclusion  This smalll sample and short-term study shows both the domestic latanoprost and Xalatan eye drops can effectively lower IOP in POAG and OHT patients, and no significant difference was found between them. (Ophthalmol CHN, 2012, 21: 111-114)

Key words: latanoprost, glaucoma, ocular hypertension, intraocular pressure