Abstract: Objective To assess the effects on refraction and intraocular pressure by early carteolol eyedrops application on eyes after laser in situ keratomileusis (LASIK). Design Prospective comparative case series. Participants 32 eyes of 32 patients with myopia undergone LASIK at Beijing Tongren Hospital were included. Methods 2% carteolol hydrochloride eye drops (15 eyes) were administered topically twice a day from the second week after LASIK to the end of the first month for patients with low to moderate myopia and through the end of the 1.5 months for patients with high myopia. 2% carteolol hydrochloride in control group (17 eyes) wasn't administered. The changes of spherical equivalent correction (SE) , the posterior corneal surface different value (Diff) and intraocular pressure (IOP) were observed preoperatively and 1 month, 3 months and 6 months after LASIK, respectively. Main Outcome Measures SE, the posterior corneal surface different value and IOP. Results The average SE of treatment group was (-0.150±0.742) D, (-0.170±0.595) D and (-0.525±0.618) D respectively at 1 month, 3 months and 6 months postoperatively, while it was (-0.258±0.581) D, (-0.290±0.657) D, and (-0.459±0.591) D respectively in the control group (all P>0.05). The posterior corneal surface Diff of treatment group was (7.47±2.326) μm, (6.60±3.158) μm, and (5.86±2.610) μm respectively at 1 month,3 months and 6 months postoperatively, while it was (6.59±3.355) μm, (7.35±3.622) μm, and (7.33±2.992) μm respectively in the control group (all P>0.05). The IOP of treatment group was (7.80±0.941)mm Hg,(8.07±1.534) mm Hg and (8.70±1.337) mm Hg respectively at 1 month, 3 months and 6 months postoperatively, while it was (9.35±2.827) mm Hg, (9.59±2.717) mm Hg and (8.73±1.580) mm Hg, respectively in the control group. The difference between the two groups was only significant (P=0.045) at 1 month. Conclusions Carteolol is effective to reduce IOP in early stage after LASIK and helpful to enhance the stability of the corneal biomechanical and the refraction. (Ophthalmol CHN, 2013, 22: 49-52)

Key words: laser in situ keratomileusis, introcular pressure, spherical equivalent, carteolol eyedrops