Ophthalmology in China ›› 2013, Vol. 22 ›› Issue (6): 393-396.

Previous Articles     Next Articles

Clinical observation on the association between risk factors related to thrombus and central retinal vein occlusion

ZHANG Peng， WANG Hai-yan， ZHANG Zi-feng， WANG Yu-sheng   

  1. Department of Ophthalmology, Fourth Military Medical University， Eye Institute of Chinese PLA， Xi’an 710032， China
  • Received:2013-09-02 Online:2013-11-25 Published:2013-12-10
  • Contact: WANG Yu-sheng, Email: Wangys003@126.com E-mail:Wangys003@126.com

Cited

3

Abstract: Objective To determine the association of risk factors related to venous thrombus with central retinal vein occlusin (CRVO). Design Case control study. Participants 268 CRVO patients (CRVO group) and  267 age matchable non-CRVO controls(control group). Methods All the participants in 2 groups were examined by carotid artery color doppler flow imaging to evaluate the incidence of atherosclerosis such as plaques of cartotid artery or increased carotid arterial intima-media thickness. Venous blood samples were drawn after all the participants fasted overnight, plasma levels of Hcys, vitamin B12 and folate were measured by automatic biochemical analyzer. The incidence of atherosclerosis in carotid artery, plasma levels of Hcys, vitamin B12 and folate were compared statistically between CRVO and control group. Main Outcome Measures Frequency of atherosclerosis in carotid artery, plasma levels of Hcys, vitamin B12， and folate. Results 174 (64.93%) of 268 patients with CRVO exhibited acarotid therosclerosis,  which was found in 147 control subjects (55.06%) (P=0.017). 180 patients (51.87%) with CRVO exhibited increased plasma levels of Hcys compared with 99 (37.08%) in  control subjects (P=0.0004). Lowered Vitamin B12 level was found in 94 patients (35.07%) with CRVO and  169(63.30%) in control subjects(P=0.0658); whereas lowered folate was found in 155 patients (57.79%) with CRVO  compared with  80 (29.96%) in control subjects (P=0.0005). Logistic regression analysis showed that carotid atherosclerosis was a risk factor for CRVO (OR=4.049, 95％CI: 1.751~8.621)，whereas elevated Hcys level (OR=2.695，95％CI: 1.477~5.714) and lowered folate (OR=0.354，95％CI: 0.237~0.576) were also shown to be significant risk factors for CRVO. Conclusion Atherosclerosis in carotid artery, elevated Hcys and lowered folate were related to CRVO. Reducing above-mentioned risk factors related to thrombus may be crucial to the prevention and treatment of CRVO.

Key words: central retinal vein occlusion, venous thrombus, atherosclerosis；homocysteine