Abstract: Objective To study the function changes of macula and its correlates with visual acuity after intravitreal Conbercept for central retinal vein occlusion (CRVO) induced macular edema (ME). Design Prospective case series. Participants 31 patients (31 eyes) with ME secondary to non-ischemia CRVO were enrolled from August 2020 to December 2020. Methods All the subjects were received Conbercept 3+PRN intravitreal injections. Before treatment and 1, 3 and 6 months after treatment, OCTA and mf-ERG were checked. Main Outcome Measures Best corrected visual acuity(BCVA) (LogMAR), amplitude density of P1 wave and implicit time of P1, N1 wave from mf-ERG ring 1 and ring 2. Results Compared to the baseline (0.87±0.27), BCVA was greatly improved at 1, 3, 6 months after treatment (0.71±0.22, 0.67±0.18, 0.51±0.14, respectively) (F=18.771, P=0.004). The implicit time of N1 wave from ring 1 at baseline and each follow-up point was 31.69±2.80 ms, 28.73±1.34 ms, 26.47±0.99 ms, 24.23±1.30 ms, respectively (F=86.023, P=0.007). The implicit time of P1 wave from ring 1 at baseline and each follow-up point was 50.52±3.80 ms, 48.68±4.01 ms, 46.43±3.35 ms, 43.59±3.69 ms, respectively (F=21.333, P=0.010). The implicit time of N1 wave from ring 2 at baseline and each follow-up point was 29.89±3.04 ms, 27.55±2.98 ms, 24.41±2.77 ms, 22.55±2.45 ms, respectively (F=38.566, P=0.002). The implicit time of P1 wave from ring 2 at baseline and each follow-up point wase 48.41±3.68 ms, 46.81±2.97 ms, 44.67±3.36 ms, 39.09±2.77 ms, respectively (F=46.681, P=0.003). The amplitude density of P1 from ring 1 at baseline and each follow-up point was 15.81±5.42 nv/deg2, 21.01±4.70 nv/deg2, 23.25±3.98 nv/deg2, 27.42±6.01 nv/deg2, respectively (F=26.622, P=0.001). The amplitude density of P1 from ring 2 at baseline and each follow-up point was 4.00±1.47 nv/deg2, 6.21±2.16 nv/deg2, 7.89±2.05 nv/deg2, 10.67±2.01 nv/deg2, respectively (F=71.764, P=0.005). Pearson correlation analysis showed there was no correlations between BCVA and the implicit time of N1 (r=0.112, P=0.609; r=0.284 P=0.188). However there was positive correlations between BCVA and the implicit time of P1(r=0.784, P=0.013; r=0.592, P=0.036) and negative correlations between BCVA and the amplitude density of P1 (r=-0.683, P=0.012; r=-0.853, P=0.010) after treatment. Conclusion Conbercept 3 + PRN injection can improve visual acuity and measured by mf-ERG macular function in patients with macular edema secondary to non ischemic central retinal vein occlusion. （Ophthalmol CHN, 2022, 31: 130-134）

Key words: non-ischemia central retinal vein occlusion, macular edema, Conbercept, multifocal electroretinogram