Abstract:

Objective To analyze the distribution and characteristics of different neuro-ophthalmic diseases. Design Retrospective case series. Participants 2166 patients with neuro-ophthalmic diseases. Methods Clinical data of hospitalized patients with neuro-ophthalmic diseases in department of neuro-ophthalmology in the Chinese PLA General Hospital from January 2015 to December 2017 were collected and the disease spectrum, age and living region distribution were analyze. Main Outcome Measures Disease constituent ratio. Results A total of 2166 patients with the male/female ratio of 1:1.2 were included in this study. The mean age at onset was 38.6±17.9 years (range 1~87 years). 348 patients (16.1%) aged below 18 years, 1582 patients  (73.0%) aged over 18 years and below 60 years, 236 patients (10.9%) aged over 60 years. The most common diseases in children included hereditary optic neuropathy (87 patients, 4.0%) with the mean onset age of 21.3±10.0 years and traumatic neuropathy (85 patients, 3.9%) with the mean onset age of 24.0±14.5 years. The disease that occurs mostly in old people was ischemic optic neuropathy (293 patients, 13.5%) with the mean onset age of 53.3±10.0 years. The most common diseases happened in men was ischemic optic neuropathy (293 patients, 13.5%), traumatic neuropathy (85 patients, 3.9%) and hereditary optic neuropathy (87 patients, 4.0%). The most common diseases in women included inflammatory demyelinate optic neuritis (838 patients, 38.7%), cerebral venous sinus thrombosis (37 patients, 1.7%) and nonorganic vision loss (21 patients, 1.0%). The three main etiology were inflammatory demyelinated optic neuritis in 838 patients  (38.7%) , nonarteritic anterior ischemic optic neuropathy in 285 patients (13.2%) and traumatic optic neuropathy in 85 patients (3.9%). Conclusion The patients with a great diversity of neuro-ophthalmic diseases are mainly young and middle-aged in this center. The optic nerve diseases, especially demyelinating optic neuritis, are particularly worth study in depth due to its high frequency. (Ophthalmol CHN, 2018, 27: 381-385)

Key words: neuro-ophthalmology, disease constituent ratio, optic neuritis