Abstract: Objective To analyze the distribution of disease subtypes and patient demographic characteristics of open-angle glaucoma (OAG) in multi-level glaucoma clinics of China. Design Retrospective case series. Participants 586 OAG patients in the glaucoma specialty clinic. Methods The diagnosis and treatment data of glaucoma specialist outpatients in Beijing Tongren Hospital (major ophthalmological center), Chengdu Integrated TCM & Western Medicine Hospital (minor ophthalmological center, group A) and Handan City Eye Hospital (minor ophthalmological center, group B) from September 2018 to February 2020 were collected. The disease subtype, gender, age and place of origin for all OAG patients were recorded. Main Outcome Measures Demographic characteristics and OAG subtype composition ratio. Results This study recorded 9584 visits of diagnosis and treatment data, and included 586 OAG patients, with an average age of 52.35±16.48 years old, and males accounted for 59.7%. Among the subtypes of OAG patients, 429 patients with primary open-angle glaucoma (POAG), accounting for 73.2%, with an average age of 51.74±16.61 years old, and more male patients, reaching 61.8%. There were 108 patients with normal-tension glaucoma (NTG), accounting for 18.4%, and the average age was 54.97±15.31 years old. Both male and female patients were 50.0%. There were 49 patients with secondary OAG, accounting for 8.4%. Compared with major ophthalmological center, the proportion of NTG in minor ophthalmological center is lower (23.0% vs. 10.6%, X2=14.06, P<0.01), and the proportion of secondary OAG is higher (5.1% vs. 13.8%, X2=13.42, P<0.01). The proportion of local patients in the major ophthalmological center was 26.8%, which was much lower than that of the minor ophthalmological center (90.8% in group A, X2=110.58, P<0.01; 96.5% in group B, X2=96.97, P<0.01). Conclusion In the glaucoma specialist clinic, the gender and age characteristics of OAG patients are similar to the past population-based survey data, and the proportion of NTG patients is lower than the results of the past population-based data. Major ophthalmological center has a higher proportion of patients from other provinces and cities, with more NTG patients and fewer secondary OAG patients than minor ophthalmological center. (Ophthalmol CHN, 2022, 31: 8-13)

Key words: primary open-angle glaucoma, normal-tension glaucoma, disease composition ratio