Abstract:  Objective To analyze the association of various clinical visual parameters with the subjective symptoms and quality of life in glaucoma patients. Design Cross-sectional study. Participants A total of 101 eyes from 101 patients diagnosed with primary open-angle glaucoma at the Ophthalmology Outpatient Department of Beijing Tongren Hospital were included(the less affected fellow eye was included in the study). Method The patients underwent evaluation of best-corrected visual acuity (BCVA, LogMAR), visual field (Humphrey perimetry, 24-2 standard mode), and contrast sensitivity (quick contrast sensitivity function）. Subjective symptoms were evaluated using the Glaucoma Symptom Scale (GSS), while quality of life was assessed with the Glaucoma Quality of Life-15 (GQL-15) Questionnaire. Spearman correlation analysis was conducted to examine the relationship between subjective questionnaire responses and visual parameters. For parameters that showed statistically significant correlations, further multiple linear regression analysis should be performed. Main Outcome Measures GSS score, GQL-15 score, visual field parameters, BCVA, contrast sensitivity parameters. Results In the 101 eyes, the mean visual field MD was (-5.59±5.30) dB, the mean BCVA was (0.004±0.049) LogMAR, and the mean area under log Contrast Sensitivity Function was 1.06±0.25. The correlation analysis showed that GSS scores were significantly correlated with the BCVA and the 12 cpd contrast sensitivity (all P<0.05), but were not significantly correlated with other visual parameters. The GQL-15 score were significantly correlated with the BCVA, the visual field MD value, the visual field PSD value, the VFI value, the area under log contrast sensitivity function, the contrast sensitivity function acuity, and the contrast sensitivity in 1, 1.5, 3, 6, 12, 18 cpd (all P<0.05). The regression analysis results showed that the MD value (P=0.028), the 12 cpd contrast sensitivity (P=0.027), and the BCVA (P=0.023) were significantly associated with the GQL-15 score after controlling for other factors. Conclusion In glaucoma patients, significant impairment in quality of life is associated with damage of visual field, best-corrected visual acuity, and contrast sensitivity.  (Ophthalmol CHN, 2025, 34: 118-122)

Key words: glaucoma, visual field, contrast sensitivity