国际眼科纵览 ›› 2026, Vol. 50 ›› Issue (2): 148-153.doi: 10.3760/cma.j.cn115500-20250415-26211

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外泌体在眼部移植物抗宿主病的应用研究

靳晓涵1 张元峰2 马俊杰2 于欣欣3 马路生2   

  1. 1 青岛大学青岛医学院,山东青岛 266000;2 青岛大学附属烟台毓璜顶医院,山东烟台 264000;3 山东第二医科大学临床医学院,山东潍坊 261053
  • 收稿日期:2025-04-15 出版日期:2026-04-22 发布日期:2026-04-22

Research of exosomes in ocular graft-versus-host disease

Jin Xiaohan1, Zhang Yuanfeng2, Ma Junjie2, Yu Xinxin3, Ma Lusheng2   

  1. 1 Qingdao University Qingdao Medical College, Qingdao Shandong 266000, China;2 Yantai Yuhuangding Hospital, Qingdao University, Yantai Shandong 264000, China;3 School of Clinical Medicine, Shandong Second Medical University, Weifang Shandong, 261053, China
  • Received:2025-04-15 Online:2026-04-22 Published:2026-04-22

摘要: 眼部移植物抗宿主病(Ocular graft-versus-host disease,oGVHD)是在异体基因造血干细胞移植后发生在眼部的一种免疫性疾病,严重影响患者的视力和生活质量。目前治疗方式存在不足,需要新的治疗靶点和方案以改进oGVHD的治疗效果。近年来,大量研究显示,外泌体作为细胞间通讯的重要介质,在oGVHD 的发病机制、诊断和治疗等方面展现出了重要价值。本文就不同来源的外泌体在oGVHD中的研究进展进行综述。


关键词: 眼部移植物抗宿主病, 外泌体, 免疫调节

Abstract: Ocular graft-versus-host disease (oGVHD) is an immune disease that occurs in the eye after allogeneic hematopoietic stem cell transplantation, which seriously affects the vision and quality of life of patients. Current treatment modalities are inadequate, and new treatment options and targets are needed to improve the therapeutic efficacy of oGVHD. In recent years, a large number of studies have shown that exosomes, as important mediators of cell-to-cell communication, have shown important value in the pathogenesis, diagnosis and treatment of oGVHD. This article reviews the research progress of exosomes from different sources in oGVHD.


Key words: Ocular graft-versus-host disease, Exosomes, Immunomodulation