Abstract: Primary open-angle glaucoma (POAG) is the most common type of glaucoma, while its pathogenesis remains elusive. In recent years, oxidative stress has been recognized as the critical role in POAG formation and progress. Specifically, excessive reactive oxygen species promote the pathogenesis of trabecular meshwork (TM), and lead to the dysfunction of aqueous humor outflow pathway, as well as intraocular pressure elevation. However, the relationship between oxidative stress and TM dysfunction is not fully understood yet. In this article, we aim to elucidate the mechanisms underlying oxidative stress-induced TM damage in POAG, including the oxidative stress sources, the responsive molecular mechanisms of TM cells exposure to oxidative stress, and the structural and functional changes of TM.(Int Rev Ophthalmol, 2024, 48:  448-453)

Key words: primary open-angle glaucoma, oxidative stress, trabecular meshwork