International Review of Ophthalmology ›› 2021, Vol. 45 ›› Issue (3): 211-215.doi: 10.3760/cma.j.issn.1673-5803.2021.03.007

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Light-induced retinal damage in the pathogenesis of age-related macular degeneration#br#
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Zhang Yumeng, Zhang Jingfa, Sun Xiaodong   

  1. Department of Ophthalmology, Shanghai General Hospital (Shanghai First People’s Hospital); National Clinical Research Center for Eye Diseases; Shanghai Key Laboratory of Ocular Fundus Diseases; Shanghai Engineering Center for Visual Science and Photomedicine; Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai 200080, China

  • Received:2020-12-22 Online:2021-06-22 Published:2021-06-22
  • Contact: Sun Xiaodong, Email: drsunxiaodong@126.com
  • Supported by:
     the National Major Scientific and Technological Special Project for “Significant New Drugs Development” during the Thirtieth Five-year Plan Period (2019ZX09301113); the Science and Technology Commission of Shanghai Municipality (19495800700)

Abstract: The etiology of age-related macular degeneration (AMD) is complex and its pathogenesis has not been fully elucidated, which is related to age, environment, genetics, oxidative stress and inflammation, etc. In rodent models of light-induced retinal damage (LIRD), the fundus demonstrated similar pathological features as seen in AMD, such as oxidative stress, inflammatory responses, endoplasmic reticulum stress, autophagy and mitophagy, DNA damage and cell senescence, aswellas neovascularization, which in turn damage its structure and function. (Int Rev Ophthalmol, 2021, 45: 211-215)

Key words: light-induced retinal damage, age-related macular degeneration, oxidative stress, autophagy, apoptosis