Abstract: Nrf2-ARE is an important anti-oxidative stress pathway,  which can regulate the expression of many antioxidants in cells,  and has a variety of biological activities such as maintaining cell oxidation-antioxidant balance,  inhibiting apoptosis,  and anti-inflammatory. MicroRNAs (miRNAs) are a type of non-coding and extremely short RNA molecules that are widely present in eukaryotes which can regulate gene expression. It has been found that a variety of miRNAs can directly or indirectly act on the Nrf2-ARE signaling pathway and regulate the expression of related genes,  promoting or inhibiting the occurrence and development of retinal oxidative damage and fundus degeneration. (Int Rev Ophthalmol,  2020,  44:  443-447)

Key words: nuclear factor erythroid 2 related factor 2-antioxidant response element, microRNA, oxidative stress, targeted regulation, fundus diseases